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A study of inbreeding and kinship in intracranial aneurysms in the Saguenay Lac-Saint-Jean region (Quebec, Canada)

  1. M. DE BRAEKELEER1,2,*,
  2. L. PéRUSSE3,4,
  3. L. CANTIN2,
  4. J.-M. BOUCHARD5,
  5. J. MATHIEU2,4

Article first published online: 28 SEP 2007

DOI: 10.1111/j.1469-1809.1996.tb01181.x

Issue

Annals of Human Genetics

Annals of Human Genetics

Volume 60, Issue 2, pages 99–104, March 1996

Additional Information

How to Cite

BRAEKELEER, M. D., PéRUSSE, L., CANTIN, L., BOUCHARD, J.-M. and MATHIEU, J. (1996), A study of inbreeding and kinship in intracranial aneurysms in the Saguenay Lac-Saint-Jean region (Quebec, Canada). Annals of Human Genetics, 60: 99–104. doi: 10.1111/j.1469-1809.1996.tb01181.x

Author Information

  1. 1

    Département des Sciences Humaines, Université du Québec à Chicoutimi, Chicoutimi, Québec, Canada

  2. 2

    Unité de Recherche Clinique, Hôpital de Chicoutimi, Chicoutimi, Québec, Canada

  3. 3

    Université Laval, Québec, Canada

  4. 4

    IREP, Université du Québec à Chicoutimi, Chicoutimi, Québec, Canada

  5. 5

    Hǒpital de l'Enfant-Jésus, Québec, Canada

*6 Département des Sciences Humaines, Université du Québec à Chicoutimi, 555 Boulevard de l'Université, Chicoutimi, Québec G7H2B1, Canada. Phone (418) 545–5011 ext. 2246. Fax (418) 545–5012

Publication History

  1. Issue published online: 28 SEP 2007
  2. Article first published online: 28 SEP 2007
  3. Received 26.5.95. Accepted 12.10.95

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Summary

The genealogies of 533 individuals with an intracranial aneurysm (IA) born in the Saguenay-Lac-Saint-Jean region, a geographically isolated area located in northeastern Quebec, were reconstructed using a population-based register. A control group consisting of three individuals of the same sex and born on the same day and in the same municipality than the IA patients was created; the genealogies of the 1599 controls were also reconstructed. The coefficients of inbreeding and kinship were calculated. Familial aggregation, i.e. the presence of IA in two or more first- to third-degree relatives, was also sought. The mean inbreeding coefficient was lower in the IA group than in the control group (7·92 × 10−4 versus 10·04 × 10−4). The mean kinship coefficient was higher in the IA group than in the control group (2·17 × 10−4 versus 1·55 × 10−4). Forty-eight IA patients (9·0%) were first-degree relatives compared to only 1·9% of the control individuals. The proportion of individuals showing familial aggregation was higher in the IA group than in the control group (29·8% and 18·6% respectively). These results strongly suggest that some IA are genetically determined in this population.

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