This work was partially supported by grants NCI-CA16672, and NIGMS GM52607-01. We would also like to thank Maureen Goode, Ph.D. for her editorial assistance.
Assessing genetic linkage and association with robust components of variance approaches
Article first published online: 28 SEP 2007
Annals of Human Genetics
Volume 60, Issue 2, pages 143–160, March 1996
How to Cite
AMOS, C. I., ZHU, D. K. and BOERWINKLE, E. (1996), Assessing genetic linkage and association with robust components of variance approaches. Annals of Human Genetics, 60: 143–160. doi: 10.1111/j.1469-1809.1996.tb01184.x
- Issue published online: 28 SEP 2007
- Article first published online: 28 SEP 2007
- Received 20.3.95. Accepted 20.10.95
Simulation studies are used to explore the properties of procedures for estimating components of variance and constructing test statistics in genetic linkage studies of quantitative traits. We evaluated the bias and median squared error of estimates of the linked additive genetic variance obtained by regression, maximum likelihood and quasilikelihood estimation procedures. The quasilikelihood and regression procedures provided unbiased estimates of the additive component of variance. Maximum likelihood procedures that assumed multivariate normality were biased for most sample sizes considered but had more precision for most generating models than regression or quasilikelihood methods did. Wald tests derived from quasilikelihood procedures had similar or greater power than Wald tests based upon estimators from maximum likelihood analyses. Quasilikelihood estimation may therefore be preferable whenever there is uncertainty about the generating distribution for the error variance, but the robustness of this approach is offset by its required computational complexity.