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Geographical Structure of the Y-chromosomal Genetic Landscape of the Levant: A coastal-inland contrast

  1. Mirvat El-Sibai1,
  2. Daniel E. Platt2,
  3. Marc Haber1,
  4. Yali Xue3,
  5. Sonia C. Youhanna1,
  6. R. Spencer Wells4,
  7. Hassan Izaabel5,
  8. May F. Sanyoura1,
  9. Haidar Harmanani1,
  10. Maziar Ashrafian Bonab6,
  11. Jaafar Behbehani7,
  12. Fuad Hashwa1,
  13. Chris Tyler-Smith3,
  14. Pierre A. Zalloua1,8,*,
  15. The Genographic Consortium9

Article first published online: 16 AUG 2009

DOI: 10.1111/j.1469-1809.2009.00538.x

Issue

Annals of Human Genetics

Annals of Human Genetics

Volume 73, Issue 6, pages 568–581, November 2009

Additional Information

How to Cite

El-Sibai, M., Platt, D. E., Haber, M., Xue, Y., Youhanna, S. C., Wells, R. S., Izaabel, H., Sanyoura, M. F., Harmanani, H., Bonab, M. A., Behbehani, J., Hashwa, F., Tyler-Smith, C., Zalloua, P. A. and The Genographic Consortium (2009), Geographical Structure of the Y-chromosomal Genetic Landscape of the Levant: A coastal-inland contrast. Annals of Human Genetics, 73: 568–581. doi: 10.1111/j.1469-1809.2009.00538.x

Author Information

  1. 1

    The Lebanese American University, Chouran, Beirut 1102 2801, Lebanon

  2. 2

    Bioinformatics and Pattern Discovery, IBM T. J. Watson Research Centre, Yorktown Hgts, NY 10598, USA

  3. 3

    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambs. CB10 1SA, UK

  4. 4

    The Genographic Project, National Geographic Society, Washington, DC 20036, USA

  5. 5

    Laboratoire de Biologie Cellulaire & Génétique Moléculaire (LBCGM), Université IBNZOHR, Agadir, Maroc

  6. 6

    Biological Sciences; University of Portsmouth, School of Biological Sciences, King Henry I Street, Portsmouth PO1 2DY, U.K.

  7. 7

    Department of Community Medicine and Behavioural Sciences, Faculty of Medicine, Kuwait University, PO Box 24923, Safat, Kuwait

  8. 8

    Harvard School of Public Health, Boston, MA 02215, USA

  9. 9

    Consortium members are listed after Acknowledgements

* *Corresponding author: Dr. Pierre Zalloua, The Lebanese American University, Chouran, Beirut 1102 2801, Lebanon. Tel: +961-1-784408 Ext. 2855; Fax: +961-9-546090; E-mail: pierre.zalloua@lau.edu.lb

Publication History

  1. Issue published online: 12 OCT 2009
  2. Article first published online: 16 AUG 2009
  3. Received: 16 May 2009Accepted: 20 July 2009

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Keywords:

  • Y chromosome;
  • Y-SNP;
  • Y-STR;
  • Levant

SUMMARY

We have examined the male-specific phylogeography of the Levant and its surroundings by analyzing Y-chromosomal haplogroup distributions using 5874 samples (885 new) from 23 countries. The diversity within some of these haplogroups was also examined. The Levantine populations showed clustering in SNP and STR analyses when considered against a broad Middle-East and North African background. However, we also found a coastal-inland, east-west pattern of diversity and frequency distribution in several haplogroups within the small region of the Levant. Since estimates of effective population size are similar in the two regions, this strong pattern is likely to have arisen mainly from differential migrations, with different lineages introduced from the east and west.

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