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Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia

  1. Gabriela Novak1,2,6,†,
  2. Martha LeBlanc1,2,†,
  3. Clement Zai5,
  4. Sajid Shaikh5,
  5. Julien Renou5,
  6. Vincenzo DeLuca5,
  7. Natalie Bulgin5,
  8. James L. Kennedy5,*,
  9. Bernard Le Foll2,3,4,*

Article first published online: 25 APR 2010

DOI: 10.1111/j.1469-1809.2010.00578.x

Issue

Annals of Human Genetics

Annals of Human Genetics

Volume 74, Issue 4, pages 291–298, July 2010

Additional Information

How to Cite

Novak, G., LeBlanc, M., Zai, C., Shaikh, S., Renou, J., DeLuca, V., Bulgin, N., Kennedy, J. L. and Le Foll, B. (2010), Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia. Annals of Human Genetics, 74: 291–298. doi: 10.1111/j.1469-1809.2010.00578.x

Author Information

  1. 1

    Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8

  2. 2

    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada

  3. 3

    Departments of Family and Community Medicine, Pharmacology, Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Canada

  4. 4

    Addiction Program, Centre for Addiction and Mental Health, Toronto, Canada

  5. 5

    Neurogenetics Section, Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, 250 College Street R-30, Toronto, Ontario, Canada M5T 1R8

  6. 6

    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada

  1. †

    These authors provided a significant contribution.

* Corresponding author for questions regarding genetic analysis: James L. Kennedy, Neurogenetics Section, CAMH, 250 College Street R-30, Toronto, Ontario M5T 1R8, Canada. Tel: (416) 979-4987; Fax: (416) 979-4666; Email: james_kennedy@camh.net
Corresponding Author: Dr. Bernard Le Foll, Translational Addiction Research Laboratory, CAMH, 33 Russell Street, Toronto, Ontario, Canada M5S 2S1. Tel: (416) 535-8501, ext. 4772; Fax: (416) 595-6922; E-mail: bernard_lefoll@camh.net

  • †

    These authors provided a significant contribution.

Publication History

  1. Issue published online: 17 JUN 2010
  2. Article first published online: 25 APR 2010
  3. Received: 13 December 2009Accepted: 16 March 2010

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Keywords:

  • Schizophrenia;
  • nicotine;
  • addiction;
  • dopamine;
  • polymorphism;
  • association;
  • gene;
  • genetic susceptibility;
  • association analysis;
  • BDNF;
  • DRD1;
  • DRD3;
  • smoking

Summary

Emerging evidence indicates that the DRD1-BDNF-DRD3 cluster plays an important role in nicotine addiction. We have performed an association analysis of 42 SNPs within these genes with cigarette consumption in a group of 341 schizophrenia patients. The ACCG haplotype consisting of four BDNF markers (Val66Met (rs6265), rs11030104, rs2049045 and rs7103411) showed an association with the risk of smoking (p = 0.0002). Both DRD1 markers tested (rs4532 and rs686) and the DRD3 marker (rs1025398) showed association with quantity of tobacco smoked (p = 0.01, 0.005 and 0.002, respectively). Our findings are preliminary; however, they support the involvement of the DRD1, BDNF and DRD3 genes in smoking behaviour.

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