These authors provided a significant contribution.
Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia
Article first published online: 25 APR 2010
© 2010 The Authors Journal compilation © 2010 Blackwell Publishing Ltd/University College London
Annals of Human Genetics
Volume 74, Issue 4, pages 291–298, July 2010
How to Cite
Novak, G., LeBlanc, M., Zai, C., Shaikh, S., Renou, J., DeLuca, V., Bulgin, N., Kennedy, J. L. and Le Foll, B. (2010), Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia. Annals of Human Genetics, 74: 291–298. doi: 10.1111/j.1469-1809.2010.00578.x
- Issue published online: 17 JUN 2010
- Article first published online: 25 APR 2010
- Received: 13 December 2009Accepted: 16 March 2010
- genetic susceptibility;
- association analysis;
Emerging evidence indicates that the DRD1-BDNF-DRD3 cluster plays an important role in nicotine addiction. We have performed an association analysis of 42 SNPs within these genes with cigarette consumption in a group of 341 schizophrenia patients. The ACCG haplotype consisting of four BDNF markers (Val66Met (rs6265), rs11030104, rs2049045 and rs7103411) showed an association with the risk of smoking (p = 0.0002). Both DRD1 markers tested (rs4532 and rs686) and the DRD3 marker (rs1025398) showed association with quantity of tobacco smoked (p = 0.01, 0.005 and 0.002, respectively). Our findings are preliminary; however, they support the involvement of the DRD1, BDNF and DRD3 genes in smoking behaviour.