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Phylogeography of the Y-chromosome haplogroup C in northern Eurasia

  1. Boris Malyarchuk1,*,
  2. Miroslava Derenko1,
  3. Galina Denisova1,
  4. Marcin Wozniak2,
  5. Tomasz Grzybowski2,
  6. Irina Dambueva3,
  7. Ilia Zakharov4

Article first published online: 20 AUG 2010

DOI: 10.1111/j.1469-1809.2010.00601.x

Issue

Annals of Human Genetics

Annals of Human Genetics

Volume 74, Issue 6, pages 539–546, November 2010

Additional Information

How to Cite

Malyarchuk, B., Derenko, M., Denisova, G., Wozniak, M., Grzybowski, T., Dambueva, I. and Zakharov, I. (2010), Phylogeography of the Y-chromosome haplogroup C in northern Eurasia. Annals of Human Genetics, 74: 539–546. doi: 10.1111/j.1469-1809.2010.00601.x

Author Information

  1. 1

    Institute of Biological Problems of the North, Russian Academy of Sciences, Portovaya str. 18, 685000 Magadan, Russia

  2. 2

    Forensic Medicine Institute, the Ludwik Rydygier Medical College, the Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland

  3. 3

    Institute of General and Experimental Biology, Russian Academy of Sciences, 670047 Ulan-Ude, Russia

  4. 4

    N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkin Str. 3, 119991 Moscow, Russia

* Corresponding author: Dr. Boris A. Malyarchuk, Genetics Laboratory, Institute of Biological Problems of the North, Portovaya str., 18, 685000 Magadan, Russia. Fax/Phone: +7 4132 634463; E-mail: malyarchuk@ibpn.ru

Publication History

  1. Issue published online: 14 OCT 2010
  2. Article first published online: 20 AUG 2010
  3. Received: 15 March 2010Accepted: 9 June 2010

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Keywords:

  • Y-chromosome;
  • haplogroup;
  • STR;
  • South Siberia;
  • Eastern Europe;
  • phylogeography

Summary

To reconstruct the phylogenetic structure of Y-chromosome haplogroup (hg) C in populations of northern Eurasia, we have analyzed the diversity of microsatellite (STR) loci in a total sample of 413 males from 18 ethnic groups of Siberia, Eastern Asia and Eastern Europe. Analysis of SNP markers revealed that all Y-chromosomes studied belong to hg C3 and its subhaplogroups C3c and C3d, although some populations (such as Mongols and Koryaks) demonstrate a relatively high input (more than 30%) of yet unidentified C3* haplotypes. Median joining network analysis of STR haplotypes demonstrates that Y-chromosome gene pools of populations studied are characterized by the presence of DNA clusters originating from a limited number of frequent founder haplotypes. These are subhaplogroup C3d characteristic for Mongolic-speaking populations, “star cluster” in C3* paragroup, and a set of DYS19 duplicated C3c Y-chromosomes. All these DNA clusters show relatively recent coalescent times (less than 3000 years), so it is probable that founder effects, including social selection resulting in high male fertility associated with a limited number of paternal lineages, may explain the observed distribution of hg C3 lineages.

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