• Agresti, A. (2002) Categorical Data Analysis. 2nd edition, New York : Wiley.
  • Bateson, W. (1907) Facts limiting the theory of heredity. Science 26, 649660.
  • Carlborg, Ö. & Haley, C. S. (2004) Epistasis: too often neglected in complex trait studies? Nat Rev Genet 5, 618625.
  • Chapman, J. & Clayton, D. (2007) Detecting association using epistatic information. Genet Epidemiol 31, 894909.
  • Christensen, R. (1990) Log-linear models. New York : Springer-Verlag.
  • Cordell, H. J. (2002) Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans. Hum Mol Genet 11, 24632468.
  • Cordell, H. J. (2009) Detecting gene-gene interactions that underlie human diseases. Nat Rev Genet 10, 392404.
  • Evans, D. M., Marchini, J., Morris, A. P. & Cardon, L. R. (2006) Two-stage two-locus models in genome-wide association. PLOS Genet 2, 14241432.
  • Fisher, R. A. (1918) The correlation between relatives on the supposition of Mendelian inheritance. Trans R Soc Edinb 52, 399433.
  • Gayán, J., Gonzáles-Pérez, A., Bermudo, F., Sáez, M. E., Royo, J. L., Quintas, A., Galan, J. J., Morón, F. J., Ramirez-Lorca, R., Real, L. M. & Ruiz, A. (2008) A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis. BMC Genomics 9, 360.
  • Hill, W. G., Goddard, M. E. & Visscher, P. M. (2009) Data and theory point to mainly additive genetic variance for complex traits. PLoS Genet 4, e10000008.
  • Li, C. & Li, M. (2008) GWAsimulator: A rapid whole-genome simulation program. Bioinformatics 24, 140142.
  • Li, W. & Reich, J. (2000) A complete enumeration and classification of two-locus disease models. Hum Hered 50, 334349.
  • Li, X., Self, S. G., Galipeau, P. C., Paulson, T. G. & Reid, B. J. (2007) Direct inference of SNP heterozygosity rate and resolution of LOH detection. PLoS Comput Biol 3, e244.
  • Marchini, J., Donnelly, P. & Cardon, L. R. (2005) Genome-wide strategies for detecting multiple loci that influence complex disease. Nat Genet 37, 413417.
  • McCullagh, P. & Nelder, J. A. (1989) Generalized linear models. 2nd Edition. London : Chapman and Hall.
  • Phillips, P. C. (2008) Epistasis—the essential role of gene interactions in the structure and evolution of genetic systems. Nat Rev Genet 9, 855867.
  • Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J. & Sham, P. C. (2007) PLINK: A tool set for whole-genome association and population-based linkage analysis. Am J Hum Genet 81, 559575.
  • Ritchie, M. D., Hahn, L. W. & Moore, J. H. (2003) Power of multifactor dimensionality reduction for detecting gene–gene interactions in the presence of genoyping error, missing data, phenotype, and genetic heterogeneity. Genet Epidemiol 24, 150157.
  • Roth, F. P., Lipshitz, H. D. & Andrews, B. J. (2009) Q&A: epistasis. J Biol 8, 35.
  • Savage, C. (1997) A survey of combinatorial Gray codes. SIAM Rev 39, 605629.
  • VanderWeele, T. J. (2010) Epistatic interactions. Statist Appl Genet Mol Biol 9, 1.
  • Westfall, P. H. & Young, S. S. (1993) Resampling-based multiple testing: Examples and methods for P-value adjustment. New York : Wiley.