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Genetic Mapping of Vascular Calcified Plaque Loci on Chromosome 16p in European Americans from the Diabetes Heart Study
Article first published online: 24 DEC 2010
DOI: 10.1111/j.1469-1809.2010.00632.x
© 2010 The Authors Annals of Human Genetics © 2010 Blackwell Publishing Ltd/University College London
Additional Information
How to Cite
Lehtinen, A. B., Cox, A. J., Ziegler, J. T., Voruganti, V. S., Xu, J., Freedman, B. I., Carr, J. J., Comuzzie, A. G., Langefeld, C. D. and Bowden, D. W. (2011), Genetic Mapping of Vascular Calcified Plaque Loci on Chromosome 16p in European Americans from the Diabetes Heart Study. Annals of Human Genetics, 75: 222–235. doi: 10.1111/j.1469-1809.2010.00632.x
Publication History
- Issue published online: 11 FEB 2011
- Article first published online: 24 DEC 2010
- Received: 10 June 2010, Accepted: 11 October 2010
References
- , , , & (1987) Diabetes and the risk of stroke. The Honolulu Heart Program. JAMA 257, 949–952.
- & (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62, 1198–1211.
- , , & (2005) Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263–265.
- , , ., , , & (2005) Quantitative trait nucleotide analysis using Bayesian model selection. Hum Biol 77, 541–559.
- , , & (1999) Oligogenic model selection using the Bayesian Information Criterion: linkage analysis of the P300 Cz event-related brain potential. Genet Epidemiol 17(Suppl 1), S67–S72.
- , , , , , , & (2005) The relationship between C-reactive protein and subclinical cardiovascular disease in the Diabetes Heart Study (DHS). Am Heart J 150, 1032–1038.
- , , , , , , , , , & (2008) Genetic epidemiology of subclinical cardiovascular disease in the diabetes heart study. Ann Hum Genet 72, 598–610.
- , , , , , , , , , & (2006) Coincident linkage of type 2 diabetes, metabolic syndrome, and measures of cardiovascular disease in a genome scan of the diabetes heart study. Diabetes 55, 1985–1994.
- , & (1989) Diabetes, intermittent claudication, and risk of cardiovascular events. The Framingham Study. Diabetes 38, 504–509.
- , , , , , ., , , & (2005) Calcified coronary artery plaque measurement with cardiac CT in population-based studies: Standardized protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) study. Radiology 234, 35–43.
- , , , , , , , , , , , , , , , & (2005) Genetic variation in selenoprotein S influences inflammatory response. Nat Genet 37, 1234–1241.
- , , , , & (2005) Efficiency and power in genetic association studies. Nat Genet 37, 1217–1223.
- , , , , , , , , , , , , , & (2008) Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med 358, 1336–1345.
- , , , , , & (2005) Coronary calcium measurements: effect of CT scanner type and calcium measure on rescan reproducibility—MESA study. Radiology 236, 477–484.
- , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , & . (2007) A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851–861.
- , , , & (2004) Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals. JAMA 291, 210–215.
- , , , & (1998) Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 339, 229–234.
- (1997) Markov chain Monte Carlo segregation and linkage analysis for oligogenic models. Am J Hum Genet, 61, 748–760.
- , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , & (2007) A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 316, 1491–1493.
- , , , , , , & (2002) Genetic basis of variation in carotid artery plaque in the San Antonio Family Heart Study. Stroke 33, 2775–2780.
- & (1979) Diabetes and cardiovascular disease. The Framingham study. JAMA 241, 2035–2038.
- , , , , & (2004) A combined linkage-physical map of the human genome. Am J Hum Genet 75, 1143–1148.
- , , , , , , & (2002) Heritability of carotid artery intima-medial thickness in type 2 diabetes. Stroke 33, 1876–1881.
- , , , , , , , , , , , , , , , , , , , , , , , , , & (2009) Finding the missing heritability of complex diseases. Nature 461, 747–53.
- & (2000) Statistical tests for detection of misspecified relationships by use of genome-screen data. Am J Hum Genet 66, 1076–1094.
- , , , , , , , , , , , & (2007) A common allele on chromosome 9 associated with coronary heart disease. Science 316, 1488–1491.
- , , , , , , & (1998) Impact of diabetes on mortality after the first myocardial infarction. The FINMONICA Myocardial Infarction Register Study Group. Diabetes Care 21, 69–75.
- , , , , & (2005) Heritability of carotid artery atherosclerotic lesions: an ultrasound study in 154 families. Stroke 36, 5–8.
- , , , , , , , , , , & (2007) Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. BMC Med Genet 8(Suppl 1), S4.
- , , , , , & (2005) iPLEX assay: Increased plexing efficiency and flexibility for MassARRAY system through single base primer extension with mass-modified terminators. Sequenom Application Note.
- , , , , , , , , & (1986) Relationship of clinical diabetes and asymptomatic hyperglycemia to risk of coronary heart disease mortality in men and women. Am J Epidemiol 123, 504–516.
- , , , , , , , & (2004) Familial aggregation and genome-wide linkage analysis of carotid artery plaque: The NHLBI family heart study. Hum Hered 57, 80–89.
- , & (2001) Use of electron beam tomography data to develop models for prediction of hard coronary events. Am Heart J 141, 375–382.
- , , & (2004) Gender-based differences in the prognostic value of coronary calcification. J Womens Health (Larchmt) 13, 273–283.
- , & (2008) Methods for handling multiple testing. Adv Genet 60, 293–308.
- , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , & (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316, 1331–1336.
- (2001) Genetic predisposition to coronary artery disease. Curr Opin Cardiol 16, 251–260.
- , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , & (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316, 1341–1345.
- , , , , , , , & (2004) Coronary calcium by spiral computed tomography predicts cardiovascular events in high-risk hypertensive patients. J Hypertens 22, 605–610.
- , & (1995) Extracoronary atherosclerotic plaque at multiple sites and total coronary calcification deposit in asymptomatic men. Association with coronary risk profile. Circulation 92, 1414–1421.
- , , , , & (2005) The F7 gene and clotting factor VII levels: dissection of a human quantitative trait locus. Hum Biol 77, 561–575.
- , , , , , , , , , & (2005) Coronary artery calcium outperforms carotid artery intima-media thickness as a noninvasive index of prevalent coronary artery stenosis. Arterioscler Thromb Vasc Biol 25, 1723–1728.
- , , , , , & (2005) Coronary calcification improves cardiovascular risk prediction in the elderly. Circulation 112, 572–577.
- , , , , & (2001) Familial aggregation of coronary artery calcium in families with type 2 diabetes. Diabetes 50, 861–866.
- , , , , , & (2004) Race-specific relationships between coronary and carotid artery calcification and carotid intimal medial thickness. Stroke 35, e97–e99.
- , , , , , , , , , , , , , , , , , , , , , , , , & (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316, 1336–1341.

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