Prevalence of Clinically Relevant UGT1A Alleles and Haplotypes in African Populations
Version of Record online: 11 FEB 2011
© 2011 The Authors Annals of Human Genetics © 2011 Blackwell Publishing Ltd/University College London
Annals of Human Genetics
Volume 75, Issue 2, pages 236–246, March 2011
How to Cite
Horsfall, L. J., Zeitlyn, D., Tarekegn, A., Bekele, E., Thomas, M. G., Bradman, N. and Swallow, D. M. (2011), Prevalence of Clinically Relevant UGT1A Alleles and Haplotypes in African Populations. Annals of Human Genetics, 75: 236–246. doi: 10.1111/j.1469-1809.2010.00638.x
- Issue online: 11 FEB 2011
- Version of Record online: 11 FEB 2011
- Received: 5 August 2010, Accepted: 29 November 2010
Table S1 Taqman primers. PBREM = phenobarbital response enhancer module
Table S2 Sequencing primers.
Table S3 Raw genotype data by country and country sub-group.
Table S4A Pairwise FST values for (TA)n for regions with significance values.
Table S4B Pairwise FST values for (TA)n for countries with significance values.
Table S4C Pairwise FST values for (TA)n ethnic/uniform country subgroups (≥40 members) with significance values.
Table S5 Pairwise D′ values for the UGT1A loci rs8175347, rs10929302, and rs11692021 in countries and ethnic groups.
Table S6p-Values with standard deviations for exact tests of differentiation of UGT1A haplotype frequencies among samples.
Table S7 Haplotypes comprising all five loci inferred using PHASE (on the separate groups), and their frequencies, for a subset of African samples compared with the probable ancestral alleles (as found in primates).
Figure S1 Diversity indices (h) for the UGT1A haplotypes encompassing loci rs8175347, rs10929302, and rs11692021.
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