Current Affiliation: Vanderbilt Epidemiology Center, Institute of Medicine and Public Health, Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, TN, USA.
Successful Aging Shows Linkage to Chromosomes 6, 7, and 14 in the Amish
Version of Record online: 14 JUN 2011
© 2011 The Authors Annals of Human Genetics © 2011 Blackwell Publishing Ltd/University College London
Annals of Human Genetics
Volume 75, Issue 4, pages 516–528, July 2011
How to Cite
Edwards, D. R. V., Gilbert, J. R., Jiang, L., Gallins, P. J., Caywood, L., Creason, M., Fuzzell, D., Knebusch, C., Jackson, C. E., Pericak-Vance, M. A., Haines, J. L. and Scott, W. K. (2011), Successful Aging Shows Linkage to Chromosomes 6, 7, and 14 in the Amish. Annals of Human Genetics, 75: 516–528. doi: 10.1111/j.1469-1809.2011.00658.x
- Issue online: 14 JUN 2011
- Version of Record online: 14 JUN 2011
- Received: 29 November 2010, Accepted: 17 March 2011
- genetic epidemiology;
- family-based study;
- population isolate
Successful aging (SA) is a multidimensional phenotype involving preservation of cognitive ability, physical function, and social engagement throughout life. Multiple components of SA are heritable, supporting a genetic component. The Amish are genetically and socially isolated with homogeneous lifestyles, making them a suitable population for studying the genetics of SA. DNA and measures of SA were collected on 214 cognitively intact Amish individuals over age 80. Individuals were grouped into a 13-generation pedigree using the Anabaptist Genealogy Database. A linkage screen of 5944 single nucleotide polymorphisms (SNPs) was performed using 12 informative subpedigrees with an affected-only 2-point and multipoint linkage analysis. Eleven SNPs produced 2-point LOD scores >2, suggestive of linkage. Multipoint linkage analyses, allowing for heterogeneity, detected significant LOD scores on chromosomes 6 (HLOD = 4.50), 7 (LOD*= 3.11), and 14 (HLOD = 4.17), suggesting multiple new loci underlying SA.