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Figure S1 Mutational spectra and ratios of Homozygotes (HOM, red) versus Compound Heterozygotes (CH, green) for each of the 6 sample examined (excluding alleles with relative frequencies <1% and grouping alleles with relative frequency between 1% and 2% in the "others" group, when present).

Figure S2qsample CI95% vs q1 plot, for a sample size of n = 25, calculated from a simulated affected population with (a) F = 0.0625 (i.e. patients born to first cousins parents) and (b) F = 0.001 (i.e. patients born to unrelated parents).

Table S1Weighted average F for (a) the Lebanese (b) the Turkish (c) the Israeli Arab, and (d) the Israeli Jews samples of patients born to unrelated individuals. Data taken from the http://www.consang.net tables

Supplementary material S1 Sample size analysis.

Supplementary material S2 Pedigrees of consanguineous patients with 1st cousin relationships between parents

FilenameFormatSizeDescription
AHG_693_sm_FigureS1-S2.doc117KSupporting info item
AHG_693_sm_SuppMatS3.doc27KSupporting info item
AHG_693_sm_SuppMatS4.doc54KSupporting info item
AHG_693_sm_SuppMatS5.doc893KSupporting info item

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