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Table S1 List of proteins used to create the alignment for ScoreCons analysis.

Table S2 Nonsense substitutions.

Table S3 Missense substitutions with in silico analysis.

Table S4 Promoter substitutions.

Table S5 Intronic variants with in silico analysis.

Table S6 Small frame-shift rearrangements.

Table S7 Large rearrangements.

Table S8 3' untranslated variant.

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