Association of the Vascular Endothelial Growth Factor Gene Polymorphisms (–460C/T, +405G/C and +936T/C) with Endometriosis: A Meta-Analysis

Authors

  • Shaohua Xu,

    Corresponding author
    1. Changzhou Maternal and Child Health Hospital, Affiliated to Nanjing Medical University, Changzhou 213000, China
      The first two authors contributed equally to this study and they should be regarded as joint first authors.
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  • Wei Wu,

    Corresponding author
    1. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China
    2. Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, China
      The first two authors contributed equally to this study and they should be regarded as joint first authors.
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  • Hong Sun,

    1. Department of Electrical Engineering, ESAT-SCD, Katholieke Universiteit Leuven, Leuven 3001, Belgium
    2. IBBT-K.U.Leuven Future Health Department, Katholieke Universiteit Leuven, Leuven 3001, Belgium
    3. Department of Microbial and Molecular Systems, Katholieke Universiteit Leuven, Leuven 3001, Belgium
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  • Jing Lu,

    1. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China
    2. Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, China
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  • Beilei Yuan,

    1. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China
    2. Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, China
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  • Yankai Xia,

    1. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China
    2. Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, China
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  • Bart De Moor,

    1. Department of Electrical Engineering, ESAT-SCD, Katholieke Universiteit Leuven, Leuven 3001, Belgium
    2. IBBT-K.U.Leuven Future Health Department, Katholieke Universiteit Leuven, Leuven 3001, Belgium
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  • Kathleen Marchal,

    1. Department of Microbial and Molecular Systems, Katholieke Universiteit Leuven, Leuven 3001, Belgium
    2. Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent 9052, Belgium
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  • Xinru Wang,

    1. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China
    2. Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, China
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  • Peizhen Xu,

    Corresponding author
    1. Changzhou Maternal and Child Health Hospital, Affiliated to Nanjing Medical University, Changzhou 213000, China
      WENJUN CHENG, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Tel: +86–25-86211033; Fax: +86–25-86662863; E-mail: wjcheng117@yahoo.com.cn or PEIZHEN XU, Changzhou Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Changzhou 213000, China. Tel: +86–25-86211033; Fax: +86–25-86662863; E-mail: hoxa1010@gmail.com
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  • Wenjun Cheng

    Corresponding author
    1. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
      WENJUN CHENG, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Tel: +86–25-86211033; Fax: +86–25-86662863; E-mail: wjcheng117@yahoo.com.cn or PEIZHEN XU, Changzhou Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Changzhou 213000, China. Tel: +86–25-86211033; Fax: +86–25-86662863; E-mail: hoxa1010@gmail.com
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The first two authors contributed equally to this study and they should be regarded as joint first authors.

WENJUN CHENG, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Tel: +86–25-86211033; Fax: +86–25-86662863; E-mail: wjcheng117@yahoo.com.cn or PEIZHEN XU, Changzhou Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Changzhou 213000, China. Tel: +86–25-86211033; Fax: +86–25-86662863; E-mail: hoxa1010@gmail.com

Summary

Published data on the association between the vascular endothelial growth factor (VEGF) gene –460C/T (rs833061), +405G/C (rs2010963), +936T/C (rs3025039) polymorphisms and endometriosis risk are inconclusive. Eleven eligible case-control studies including 2690 cases and 2803 controls were included in this meta-analysis through searching the databases of PubMed and CBMdisc (up to August 1, 2011). In the overall analysis, no significant association between the –460C/T and +405G/C polymorphisms and risk of endometriosis was observed. However, significant associations were observed between endometriosis risk and VEGF+936T polymorphism with summarized odds ratio of 1.19 (95%CI, 1.02–1.37), 1.18 (95%CI, 1.03–1.37), 1.15 (95%CI, 1.01–1.30) for CT versus CC genotype, dominant mode (CT/TT vs. CC) and allele comparison (T vs. C), respectively. Furthermore, stratified analysis showed that significantly strong association between +936T/C polymorphism and endometriosis was present only in stage III–IV (OR = 1.32 for dominant mode; OR = 1.30 for T vs. C), but not in stage I–II. However, no significantly increased risk of endometriosis was found in any of the genetic models in Asians or in Caucasians. This meta-analysis supports that VEGF+936T/C polymorphism is capable of causing endometriosis susceptibility.

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