• 1000 Genomes Project Consortium. (2010) A map of human genome variation from population-scale sequencing. Nature 467, 10611073.
  • Cambon-Thomsen, A. (2003) Assessing the impact of biobanks. Nat Genet 34, 2526.
  • Cardon L. R. & Bell, J. I. (2001) Association study designs for complex diseases. Nat Rev Genet 2, 9199.
  • Colhoun, H. M., McKeigue, P. M. & Davey Smith, G. (2003) Problems of reporting genetic associations with complex outcomes. Lancet 361, 865872.
  • Gaunt, T. R., Rodriguez, S. & Day, I. N. M. (2007) Cubic exact solutions for the estimation of pairwise haplotype frequencies: Implications for linkage disequilibrium analyses and a web tool ‘CubeX’. BMC Bioinformat 8:428.
  • Gaunt, T. R., Shah, S., Nelson, C. P., Drenos, F., Braund, P. S., Adeniran, I., Folkersen, L., Lawlor, D. A., Casas, J. P., Amuzu, A., Kivimaki, M., Whittaker, J., Eriksson, P., Zhang, H., Hancox, J. C., Tomaszewski, M., Burton, P. R., Tobin, M. D., Humphries, S. E., Talmud, P. J., Macfarlane, P. W., Hingorani, A. D., Samani, N. J., Kumari, M. & Day, I. N. M. (2012) Integration of genetics into a systems model of cardiac conduction traits using HumanCVD BeadChip. Circulation Cardiovascular Genetics, in press.
  • Hill, W. G. & Robertson, A. (1968) Linkage disequilibrium in finite populations. Theor Appl Genet 33, 226231.
  • Howie, B. N., Donnelly, P. & Marchini, J. (2009) A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet 5:e1000529.
  • Ioannidis, J. P. A., Gwinn, M., Little, J., Higgins, J. P. T., Bernstein, J. L., Boffetta, P., Bondy, M., Bray, M. S., Brenchley, P. E., Buffler, P. A., Casas, J. P., Chokkalingam, A., Danesh, J., Smith, G. D., Dolan, S., Duncan, R., Gruis, N. A., Hartge, P., Hashibe, M., Hunter, D. J., Jarvelin, M. R., Malmer, B., Maraganore, D. M., Newton-Bishop, J. A., O'Brien, T. R., Petersen, G., Riboli, E., Salanti, G., Seminara, D., Smeeth, L., Taioli, E., Timpson, N., Uitterlinden, A. G., Vineis, P., Wareham, N., Winn, D. M., Zimmern, R. & Khoury, M. J. (2006) A road map for efficient and reliable human genome epidemiology. Nat Genet 38, 35.
  • Kathiresan, S., Melander, O., Guiducci, C., Surti, A., Burtt, N. P., Rieder, M. J., Cooper, G. M., Roos, C., Voight, B. F., Havulinna, A. S., Wahlstrand, Br, Hedner, T., Corella, D., Tai, E. S., Ordovas, J. M., Berglund, G., Vartiainen, E., Jousilahti, P., Hedblad, B., Taskinen, M. R., Newton-Cheh, C., Salomaa, V., Peltonen, L., Groop, L., Altshuler, D. M. & Orho-Melander, M. (2008) Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet 40, 189197.
  • Lawlor, D. A., Bedford, C., Taylor, M. & Ebrahim, S. (2003) Geographical variation in cardiovascular disease, risk factors, and their control in older women: British Women's Heart and Health Study. J Epidemiol Commun Health 57, 134140.
  • Lewontin, R. C. (1964) The Interaction of Selection and Linkage. Part I. General Considerations; Heterotic Models. Genetics 49, 4967.
  • Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J. & Sham, P. C. (2007) PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81, 559575.
  • Raistrick, C. A., Alharbi, K. K., Day, I. N. M. & Gaunt, T. R. (2011) Analysis of potential genomic confounding in genetic association studies and an online genomic confounding browser (GCB). Ann Hum Genet 75, 723731.
  • Seminara, D., Khoury, M. J., O'Brien, T. R., Manolio, T., Gwinn, M. L., Little, J., Higgins, J. P. T., Bernstein, J. L., Boffetta, P., Bondy, M., Bray, M. S., Brenchley, P. E., Buffler, P. A., Casas, J. P., Chokkalingam, A. P., Danesh, J., Davey Smith, G., Dolan, S., Duncan, R., Gruis, N. A., Hashibe, M., Hunter, D., Jarvelin, M. R., Malmer, B., Maraganore, D. M., Newton-Bishop, J. A., Riboli, E., Salanti, G., Taioli, E., Timpson, N., Uitterlinden, A. G., Vineis, P., Wareham, N., Winn, D. M., Zimmern, R. & Ioannidis, J. P. A. (2007) The emergence of networks in human genome epidemiology: Challenges and opportunities. Epidemiology 18, 18.
  • Smith, A. J. P., Palmen, J., Putt, W., Talmud, P. J., Humphries, S. E. & Drenos, F. (2010) Application of statistical and functional methodologies for the investigation of genetic determinants of coronary heart disease biomarkers: Lipoprotein lipase genotype and plasma triglycerides as an exemplar. Hum Mol Genet 19, 39363947.
  • Talmud, P. J., Drenos, F., Shah, S., Shah, T., Palmen, J., Verzilli, C., Gaunt, T. R., Pallas, J., Lovering, R., Li, K., Casas, J. P., Sofat, R., Kumari, M., Rodriguez, S., Johnson, T., Newhouse, S. J., Dominiczak, A., Samani, N. J., Caulfield, M., Sever, P., Stanton, A., Shields, D. C., Padmanabhan, S., Melander, O., Hastie, C., Delles, C., Ebrahim, S., Marmot, M. G., Smith, G. D., Lawlor, D. A., Munroe, P. B., Day, I. N., Kivimaki, M., Whittaker, J., Humphries, S. E. & Hingorani, A. D. (2009) Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet 85, 628642.
  • The Internatioal HapMap Consortium, Altshuler, D. M., Gibbs, R. A., Peltonen, L., Altshuler, D. M., Gibbs, R. A., Peltonen, L., Dermitzakis, E., Schaffner, S. F., Yu, F., Peltonen, L., Dermitzakis, E., Bonnen, P. E., Altshuler, D. M., Gibbs, R. A., de Bakker, P. I. W., Deloukas, P., Gabriel, S. B., Gwilliam, R., Hunt, S., Inouye, M., Jia, X., Palotie, A., Parkin, M., Whittaker, P., Yu, F., Chang, K., Hawes, A., Lewis, L. R., Ren, Y., Wheeler, D., Gibbs, R. A., Muzny, D. M., Barnes, C., Darvishi, K., Hurles, M., Korn, J. M., Kristiansson, K., Lee, C., McCarrol, S. A., Nemesh, J., Dermitzakis, E., Keinan, A., Montgomery, S. B., Pollack, S., Price, A. L., Soranzo, N., Bonnen, P. E., Gibbs, R. A., Gonzaga-Jauregui, C., Keinan, A., Price, A. L., Yu, F., Anttila, V., Brodeur, W., Daly, M. J., Leslie, S., McVean, G., Moutsianas, L., Nguyen, H., Schaffner, S. F., Zhang, Q., Ghori, M. J. R., McGinnis, R., McLaren, W., Pollack, S., Price, A. L., Schaffner, S. F., Takeuchi, F., Grossman, S. R., Shlyakhter, I., Hostetter, E. B., Sabeti, P. C., Adebamowo, C. A., Foster, M. W., Gordon, D. R., Licinio, J., Manca, M. C., Marshall, P. A., Matsuda, I., Ngare, D., Wang, V. O., Reddy, D., Rotimi, C. N., Royal, C. D., Sharp, R. R., Zeng, C., Brooks, L. D. & McEwen, J. E. (2010) Integrating common and rare genetic variation in diverse human populations. Nature 467, 5258.
  • Zeggini, E., Rayner, W., Morris, A. P., Hattersley, A. T., Walker, M., Hitman, G. A., Deloukas, P., Cardon, L. R. & McCarthy, M. I. (2005) An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets. Nat Genet 37, 13201322.