The first two authors contributed equally to this review.
Slit–Robo interactions during cortical development
Article first published online: 6 JUN 2007
Journal of Anatomy
Volume 211, Issue 2, pages 188–198, August 2007
How to Cite
Andrews, W. D., Barber, M. and Parnavelas, J. G. (2007), Slit–Robo interactions during cortical development. Journal of Anatomy, 211: 188–198. doi: 10.1111/j.1469-7580.2007.00750.x
- Issue published online: 6 JUN 2007
- Article first published online: 6 JUN 2007
- Accepted for publication 22 March 2007
- developing cortex;
- neuronal migration;
Interneurons are an integral part of cortical neuronal circuits. During the past decade, numerous studies have shown that these cells, unlike their pyramidal counterparts that are derived from the neuroepithelium along the lumen of the lateral ventricles, are generated in the ganglionic eminences in the subpallium. They use tangential migratory paths to reach the cortex, guided by intrinsic and extrinsic cues. Evidence is now emerging which suggests that the family of Slit proteins, acting through Robo receptors, play a role not only in axon guidance in the developing forebrain, but also as guiding signals in the migration of cortical interneurons. Here we describe the patterns of expression of Slit and Robo at different stages of forebrain development and review the evidence in support of their role in cortical interneuron migration. Slit–Robo signal transduction mechanisms are also important during normal development in a number of systems in the body and in disease states, making them potential therapeutic targets for the treatment of neurological disorders and certain types of cancer.