G1 to S phase cell cycle transition in somatic and embryonic stem cells

Authors

  • Irina Neganova,

    1. North East Institute for Stem Cell Research and
    2. Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Newcastle NE1 3BZ, UK
    Search for more papers by this author
  • Majlinda Lako

    1. North East Institute for Stem Cell Research and
    2. Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Newcastle NE1 3BZ, UK
    Search for more papers by this author

Dr Majlinda Lako, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK. T: +44 191 241 8688; F: +44 191 241 8666; E: Majlinda.Lako@ncl.ac.uk

Abstract

It is well known that G1 to S phase transition is tightly regulated by the expression and phosphorylation of a number of well-characterized cyclins, cyclin-dependent kinases and members of the retinoblastoma gene family. In this review we discuss the role of these components in regulation of G1 to S phase transition in somatic cells and human embryonic stem cells. Most importantly, we discuss some new tenable links between maintenance of pluripotency and cell cycle regulation in embryonic stem cells by describing the role that master transcription factors play in this process. Finally, the differences in cell cycle regulation between murine and human embryonic stem cells are highlighted, raising interesting questions regarding their biology and stages of embryonic development from which they have been derived.

Ancillary