Development in infants with autism spectrum disorders: a prospective study
Article first published online: 26 APR 2006
Journal of Child Psychology and Psychiatry
Volume 47, Issue 6, pages 629–638, June 2006
How to Cite
Landa, R. and Garrett-Mayer, E. (2006), Development in infants with autism spectrum disorders: a prospective study. Journal of Child Psychology and Psychiatry, 47: 629–638. doi: 10.1111/j.1469-7610.2006.01531.x
- Issue published online: 26 APR 2006
- Article first published online: 26 APR 2006
- Manuscript accepted 25 April 2005
- autism spectrum disorder;
- autistic disorder;
- language impairment;
- language delay;
- language disorder;
- motor skills;
- pervasive developmental disorder;
Background: Autism is rarely diagnosed before three years of age despite evidence suggesting prenatal abnormalities in neurobiological processes. Little is known about when or how development becomes disrupted in the first two years of life in autism. Such information is needed to facilitate early detection and early intervention.
Methods: This prospective study of autism spectrum disorders (ASD) examined development using the Mullen Scales of Early Learning (MSEL) in 87 infants tested at target ages 6, 14, and 24 months. Participants came from infants at high risk (siblings of children with autism) and low risk (no family history of autism) groups. Based on language test scores, Autism Diagnostic Observation Schedule, and clinical judgment at 24 months of age, participants were categorized as: unaffected, ASD, or language delayed (LD). Longitudinal linear regression and ANOVA models were applied to MSEL raw scores, and estimates were compared between the three diagnostic groups.
Results: No statistically significant group differences were detected at 6 months. By 14 months of age, the ASD group performed significantly worse than the unaffected group on all scales except Visual Reception. By 24 months of age, the ASD group performed significantly worse than the unaffected group in all domains, and worse than the language delayed group in Gross Motor, Fine Motor, and Receptive Language. The developmental trajectory of the ASD group was slower than the other groups’, and showed a significant decrease in development between the first and second birthdays.
Conclusions: Variations from typical and language delayed development are detectable in many children with ASD using a measure of general development by 24 months of age. Unusual slowing in performance occurred between 14 and 24 months of age in ASD.