Conflict of interest statement: No conflicts declared.
Research Review: A neuroscience framework for pediatric anxiety disorders
Article first published online: 5 JUN 2007
Journal of Child Psychology and Psychiatry
Volume 48, Issue 7, pages 631–648, July 2007
How to Cite
Pine, D. S. (2007), Research Review: A neuroscience framework for pediatric anxiety disorders. Journal of Child Psychology and Psychiatry, 48: 631–648. doi: 10.1111/j.1469-7610.2007.01751.x
- Issue published online: 5 JUN 2007
- Article first published online: 5 JUN 2007
- Manuscript accepted 8 January 2007
- children and axdolescents;
- prefrontal cortex;
Across a range of mammalian species, early developmental variations in fear-related behaviors constrain patterns of anxious behavior throughout life. Individual differences in anxiety among rodents and non-human primates have been shown to reflect early-life influences of genes and the environment on brain circuitry. However, in humans, the manner in which genes and the environment developmentally shape individual differences in anxiety and associated brain circuitry remains poorly specified. The current review presents a conceptual framework that facilitates clinical research examining developmental influences on brain circuitry and anxiety. Research using threat-exposure paradigms might most directly integrate basic and clinical perspectives on pediatric anxiety.