Conflict of interest statement: No conflicts declared.
Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genes
Article first published online: 28 JUL 2008
© 2008 The Authors. Journal compilation © 2008 Association for Child and Adolescent Mental Health
Journal of Child Psychology and Psychiatry
Volume 49, Issue 9, pages 950–957, September 2008
How to Cite
Loo, S. K., Rich, E. C., Ishii, J., McGough, J., McCracken, J., Nelson, S. and Smalley, S. L. (2008), Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genes. Journal of Child Psychology and Psychiatry, 49: 950–957. doi: 10.1111/j.1469-7610.2008.01928.x
- Issue published online: 27 AUG 2008
- Article first published online: 28 JUL 2008
- Manuscript accepted 25 February 2008
- working memory;
- executive function;
- parent psychopathology
Background: This paper examines familiality and candidate gene associations of cognitive measures as potential endophenotypes in attention-deficit/hyperactivity disorder (ADHD).
Methods: The sample consists of 540 participants, aged 6 to 18, who were diagnosed with ADHD from 251 families recruited for a larger genetic study of ADHD. All members of the family underwent psychiatric interviews and children were administered a large battery of cognitive tasks. Subjects were genotyped for several dopaminergic candidate genes (DAT1, DRD4, and DRD5).
Results: Performance on measures of intelligence, working memory, and set-shifting had the highest sibling correlations and exhibited significant familial clustering. The 7-repeat allele of the dopamine receptor D4 (DRD4) gene was associated with poor performance on measures of intelligence, color naming, interference control, and working memory. There were no significant associations with DAT1 and DRD5.
Conclusions: Sibling correlations, familial clustering and candidate gene associations provide strong support for verbal working memory as a candidate endophenotype for ADHD. More complex models of, and larger sample sizes for, genetic association with cognitive functions are encouraged for future study.