Conflict of interest statement: No conflicts declared.
Gene–environment interplay between peer rejection and depressive behavior in children
Article first published online: 26 MAY 2009
© 2009 The Authors. Journal compilation © 2009 Association for Child and Adolescent Mental Health
Journal of Child Psychology and Psychiatry
Volume 50, Issue 8, pages 1009–1017, August 2009
How to Cite
Brendgen, M., Vitaro, F., Boivin, M., Girard, A., Bukowski, W. M., Dionne, G., Tremblay, R. E. and Pérusse, D. (2009), Gene–environment interplay between peer rejection and depressive behavior in children. Journal of Child Psychology and Psychiatry, 50: 1009–1017. doi: 10.1111/j.1469-7610.2009.02052.x
- Issue published online: 16 JUL 2009
- Article first published online: 26 MAY 2009
- Manuscript accepted 15 October 2008
- Gene–environment interaction;
- gene–environment correlation;
- depressive behavior;
- peer rejection;
- behavioral genetics
Background: Genetic risk for depressive behavior may increase the likelihood of exposure to environmental stressors (gene–environment correlation, rGE). By the same token, exposure to environmental stressors may moderate the effect of genes on depressive behavior (gene–environment interaction, G×E). Relating these processes to a peer-related stressor in childhood, the present study examined (1) whether genetic risk for depressive behavior in children is related to higher levels of rejection by the peer group (rGE) and (2) whether peer rejection moderates the effect of genetic factors on children’s depressive behavior (G×E).
Methods: The sample comprised 336 twin pairs (MZ pairs = 196, same-sex DZ pairs = 140) assessed in kindergarten (mean age 72.7 months). Peer acceptance/rejection was measured via peer nominations. Depressive behavior was measured through teacher ratings.
Results: Consistent with rGE, a moderate overlap of genetic effects was found between peer acceptance/rejection and depressive behavior. In line with G×E, genetic effects on depressive behavior varied across levels of peer acceptance/rejection.
Conclusions: An increased genetic disposition for depressive behavior is related to a higher risk of peer rejection (rGE). However, genes play a lesser role in explaining individual differences in depressive behavior in rejected children than in accepted children (G×E).