Conflict of interest statement: No conflicts declared.
Research Review: Cholinergic mechanisms, early brain development, and risk for schizophrenia
Article first published online: 18 NOV 2009
© 2009 The Authors. Journal compilation © 2009 Association for Child and Adolescent Mental Health
Journal of Child Psychology and Psychiatry
Volume 51, Issue 5, pages 535–549, May 2010
How to Cite
Ross, R. G., Stevens, K. E., Proctor, W. R., Leonard, S., Kisley, M. A., Hunter, S. K., Freedman, R. and Adams, C. E. (2010), Research Review: Cholinergic mechanisms, early brain development, and risk for schizophrenia. Journal of Child Psychology and Psychiatry, 51: 535–549. doi: 10.1111/j.1469-7610.2009.02187.x
- Issue published online: 1 APR 2010
- Article first published online: 18 NOV 2009
- Manuscript accepted 1 September 2009
The onset of diagnostic symptomology for neuropsychiatric diseases is often the end result of a decades-long process of aberrant brain development. Identification of novel treatment strategies aimed at normalizing early brain development and preventing mental illness should be a major therapeutic goal. However, there are few models for how this goal might be achieved. This review uses the development of a psychophysiological correlate of attentional deficits in schizophrenia to propose a developmental model with translational primary prevention implications. Review of genetic and neurobiological studies suggests that an early interaction between α7 nicotinic receptor density and choline availability may contribute to the development of schizophrenia-associated attentional deficits. Therapeutic implications, including perinatal dietary choline supplementation, are discussed.