Role of Joint Receptors in Modulation of Inspiratory Intercostals Activity by Rib Motion in Dogs


  • André De Troyer

    1. Laboratory of Cardiorespiratory Physiology, Brussels School of Medicine and the *Chest Service, Erasme University Hospital, 1070 Brussels, Belgium
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  • 1Inspiratory activity in the canine external intercostal muscles is exquisitely sensitive to the direction and amplitude of the inspiratory displacement of the ribs. This study was designed to investigate the role of muscle receptors, in particular the muscle spindles, in mediating this phenomenon.
  • 2External intercostal inspiratory activity showed a reflex increase when the normal cranial motion of the ribs and the normal shortening of the muscles was reduced, and showed a reflex decrease when the cranial motion of the ribs and the shortening of the muscles was augmented. However, clamping the two ribs making up the interspace and maintaining muscle length constant only moderately attenuated these responses.
  • 3These persistent responses remained unchanged after section of the levator costae muscles.
  • 4The responses were attenuated but still present after section of the external intercostals in the contiguous segments and denervation of the internal intercostals.
  • 5These reflex responses are therefore mediated in part by non-muscular receptors, which most likely lie within the costovertebral joints. These joint receptors might be a primary determinant of the load-compensating reflex.