Spatial Patterns of Fasting and Fed Antropyloric Pressure Waves in Humans

Authors


Abstract

  • 1Gastric mechanics were investigated by categorizing the temporal and spatial patterning of pressure waves associated with individual gastric contractions.
  • 2In twelve healthy volunteers, intraluminal pressures were monitored from nine side hole recording points spaced at 1.5 cm intervals along the antrum, pylorus and duodenum.
  • 3Pressure wave sequences that occurred during phase II fasting contractions (n= 221) and after food (n= 778) were evaluated.
  • 4The most common pattern of pressure wave onset along the antrum was a variable combination of antegrade, synchronous and retrograde propagation between side hole pairs. This variable pattern accounted for 42% of sequences after food, and 34% during fasting (P < 0.05). Other common pressure wave sequence patterns were: purely antegrade - 29% after food and 42% during fasting (P < 0.05); purely synchronous - 23% fed and 17% fasting; and purely retrograde - 6% fed and 8% fasting. The length of sequences was shorter after food (P < 0.05). Some sequences ‘skipped’ individual recording points.
  • 5The spatial patterning of gastric pressure wave sequences is diverse, and may explain the differing mechanical outcomes among individual gastric contractions.
  • 6Better understanding of gastric mechanics may be gained from temporally precise correlations of luminal flows and pressures and gastric wall motion during individual gastric contraction sequences.

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