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A repolarization-induced transient increase in the outward current of the inward rectifier K+ channel in guinea-pig cardiac myocytes

  1. Keiko Ishihara,
  2. Tsuguhisa Ehara

Article first published online: 22 SEP 2004

DOI: 10.1111/j.1469-7793.1998.755bj.x

Issue

The Journal of Physiology

The Journal of Physiology

Volume 510, Issue 3, pages 755–771, August 1998

Additional Information

How to Cite

Ishihara, K. and Ehara, T. (1998), A repolarization-induced transient increase in the outward current of the inward rectifier K+ channel in guinea-pig cardiac myocytes. The Journal of Physiology, 510: 755–771. doi: 10.1111/j.1469-7793.1998.755bj.x

Author Information

  1. Department of Physiology, Saga Medical School, Saga 849-8501, Japan

*Corresponding author K. Ishihara: Department of Physiology, Saga Medical School, 5-1-1Nabeshima, Saga 849-8501, Japan. Email: keiko@post.saga-med.ac.jp

Publication History

  1. Issue published online: 22 SEP 2004
  2. Article first published online: 22 SEP 2004
  3. (Received 10 October 1997; accepted after revision 20 April 1998)

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  • Carmeliet, E. (1982). Induction and removal of inward-going rectification in sheep cardiac purkinje fibres. The Journal of Physiology 327, 285–308.
  • Carmeliet, E. (1993). Mechanisms and control of repolarization. European Heart Journal 14 (supplement H), 3–13.
  • Cranefield, P. F. & Aronson, R. S. (1988). Cardiac Arrhythmias: the Role of Triggered Activity and Other Mechanisms. Futura Publishing Company, New York .
  • Fabiato, A. & Fabiato, F. (1979). Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. Journal de Physiologie 75, 463–505.
  • Fakler, B., Brändle, U., Glowatzki, E., Weidemann, S., Zenner, H.-P. & Ruppersberg, J. P. (1995). Strong voltage-dependent inward rectification of inward rectifier K+ channels is caused by intracellular spermine. Cell 80, 149–154.
  • Fan, Z. & Hiraoka, M. (1991). Depression of delayed outward K+ current by Co2+ in guinea pig ventricular myocytes. American Journal of Physiology 261, C23–31.
  • Ficker, E., Taglialatela, M., Wible, B. A., Henley, C. M. & Brown, A. M. (1994). Spermine and spermidine as gating molecules for inward rectifier K+ channels. Science 266, 1068–1072.
  • Giles, W. R. & Imaizumi, Y. (1988). Comparison of potassium currents in rabbit atrial and ventricular cells. The Journal of Physiology 405, 123–145.
  • Hamill, O. P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F. J. (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Archiv 391, 85–100.
  • Hirano, Y. & Hiraoka, M. (1988). Barium-induced automatic activity in isolated ventricular myocytes from guinea-pig hearts. The Journal of Physiology 395, 455–472.
  • Hiraoka, M., Sunami, A., Zheng, F. & Sawanobori, T. (1992). Multiple ionic mechanisms of early afterdepolarizations in isolated ventricular myocytes from guinea-pig hearts. In QT Prolongation and Ventricular Arrhythmias, ed. Hashiba, K., Moss, A. J. & Schwartz, P. J., pp. 33–47. New York Academy of Sciences, New York .
  • Ibarra, J., Morley, G. E. & Delmar, M. (1991). Dynamics of the inward rectifier K+ current during the action potential of guinea pig ventricular myocytes. Biophysical Journal 60, 1534–1539.
  • Imoto, Y., Ehara, T. & Matsuura, H. (1987). Voltage- and time-dependent block of iK1 underlying Ba2+-induced ventricular automaticity. American Journal of Physiology 252, H325–333.
  • Isenberg, G. & Klöckner, U. (1982). Calcium tolerant ventricular myocytes prepared by preincubation in a ‘KB medium. Pflügers Archiv 395, 6–18.
  • Ishihara, K. (1997). Time-dependent outward currents through the inward rectifier potassium channel IRK1: the role of weak blocking molecules. Journal of General Physiology 109, 229–243.
  • Ishihara, K., Hiraoka, M. & Ochi, R. (1996). The tetravalent organic cation spermine causes the gating of the IRK1 channel expressed in murine fibroblast cells. The Journal of Physiology 491, 367–381.
  • Ishihara, K., Mitsuiye, T., Noma, A. & Takano, M. (1989). The Mg2+ block and intrinsic gating underlying inward rectification of the K+ current in guinea-pig cardiac myocytes. The Journal of Physiology 419, 297–320.
  • January, C. T. & Moscucci, A. (1992). Cellular mechanisms of early afterdepolarizations. In QT Prolongation and Ventricular Arrhythmias, ed. Hashiba, K., Moss, A. J. & Schwartz, P. J., pp. 23–32. New York Academy of Sciences, New York .
  • Kiyosue, T., Arita, M., Muramatsu, H., Spindler, A. J. & Noble, D. (1993). Ionic mechanisms of action potential prolongation at low temperature in guinea-pig ventricular myocytes. The Journal of Physiology 468, 85–106.
  • Kurachi, Y. (1985). Voltage-dependent activation of the inward-rectifier potassium channel in the ventricular cell membrane of guinea-pig heart. The Journal of Physiology 366, 365–385.
  • Lopatin, A. N., Makhina, E. N. & Nichols, C. G. (1994). Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature 372, 366–369.
  • Lopatin, A. N., Makhina, E. N. & Nichols, C. G. (1995). The mechanism of inward rectification of potassium channels: ‘long-pore plugging’ by cytoplasmic polyamines. Journal of General Physiology 106, 923–955.
  • Lopatin, A. N. & Nichols, C. G. (1996). [K+] dependence of polyamine-induced rectification in inward rectifier potassium channels (IRK1, Kir2.1). Journal of General Physiology 108, 105–113.
  • Matsuda, H. (1988). Open-state substructure of inwardly rectifying potassium channels revealed by magnesium block in guinea-pig heart cells. The Journal of Physiology 397, 237–258.
  • Matsuda, H., Saigusa, A. & Irisawa, H. (1987). Ohmic conductance through the inwardly rectifying K channel and blocking by internal Mg2+. Nature 325, 156–159.
  • Murphy, E., Freudenrich, C. C. & Lieberman, M. (1991). Cellular magnesium and Na/Mg exchange in heart cells. Annual Review of Physiology 53, 273–287.
  • Noble, D. (1975). The Initiation of the Heartbeat. Oxford University Press, London .
  • Ohmori, H. (1978). Inactivation kinetics and steady-state current noise in the anomalous rectifier of tunicate egg cell membranes. The Journal of Physiology 281, 77–99.
  • Oliva, C., Cohen, I. S. & Pennefather, P. (1990). The mechanism of rectification of iK1 in canine Purkinje myocytes. Journal of General Physiology 96, 299–318.
  • Omori, K., Oishi, K. & Matsuda, H. (1997). Inwardly rectifying potassium channels expressed by gene transfection into the Green Monkey kidney cell line COS-1. The Journal of Physiology 499, 369–378.
  • Powell, T., Terrar, D. A. & Twist, V. W. (1980). Electrical properties of individual cells isolated from adult rat ventricular myocardium. The Journal of Physiology 302, 131–153.
  • Root, M. J. & MacKinnon, R. (1994). Two identical noninteracting sites in an ion channel revealed by proton transfer. Science 265, 1852–1856.
  • Sanguinetti, M. C. & Jurkiewicz, N. K. (1990). Two components of cardiac delayed rectifier K+ current: differential sensitivity to block by class III antiarrythmic agents. Journal of General Physiology 96, 195–215.
  • Shimoni, Y., Clark, R. B. & Giles, W. R. (1992). Role of an inwardly rectifying potassium current in rabbit ventricular action potential. The Journal of Physiology 448, 709–727.
  • Silver, M. R. & DeCoursey, T. E. (1990). Intrinsic gating of inward rectifier in bovine pulmonary artery endothelial cells in the presence or absence of internal Mg2+. Journal of General Physiology 96, 109–133.
  • Stanfield, P. R., Davies, N. W., Shelton, P. A., Khan, I. A., Brammar, W. J., Standen, N. B. & Conley, E. C. (1994). The intrinsic gating of inward rectifier K+ channels expressed from the murine IRK1 gene depends on voltage, K+ and Mg2+. The Journal of Physiology 475, 1–7.
  • Suzuki, T., He, Y., Kashiwagi, K., Murakami, Y., Hayashi, S. & Igarashi, K. (1994). Antizyme protects against abnormal accumulation and toxicity of polyamines in ornithine decarboxylase-overproducing cells. Proceedings of the National Academy of Sciences of the USA 91, 8930–8934.
  • Tourneur, Y., Mitra, R., Morad, M. & Rougier, O. (1987). Activation properties of the inward-rectifying potassium channel on mammalian heart cells. Journal of Membrane Biology 97, 127–135.
  • Vandenberg, C. A. (1987). Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ions. Proceedings of the National Academy of Sciences of the USA 84, 2560–2564.
  • Yang, J., Jan, Y. N. & Jan, L. Y. (1995). Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel. Neuron 14, 1047–1054.
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