A trauma-like elevation of plasma cytokines in humans in response to treadmill running
Article first published online: 22 SEP 2004
The Journal of Physiology
Volume 513, Issue 3, pages 889–894, December 1998
How to Cite
Ostrowski, K., Hermann, C., Bangash, A., Schjerling, P., Nielsen, J. N. and Pedersen, B. K. (1998), A trauma-like elevation of plasma cytokines in humans in response to treadmill running. The Journal of Physiology, 513: 889–894. doi: 10.1111/j.1469-7793.1998.889ba.x
- Issue published online: 22 SEP 2004
- Article first published online: 22 SEP 2004
- (Received 4 June 1998; accepted after revision 14 September 1998)
- 1Elevated levels of cytokines, especially interleukin (IL)-6 and IL-1ra, can be measured in the plasma of athletes after exhaustive long term exercise.
- 2The present study investigates the kinetics of several cytokines and chemokines in ten male athletes before, during and after 2.5 h of treadmill running at 75% of maximal oxygen consumption (VO2,max). Blood was sampled before, every half-hour during running and every hour in the following 6 h recovery period.
- 3The plasma concentration of IL-6 increased after 30 min of running, and peaked at the end of running with a 25-fold increase compared with the pre-exercise value. IL-1ra increased only after running, and peaked after 2 h of rest with an 18-fold increase compared with the pre-exercise value. No changes were found in the concentrations of IL-1β, tumour necrosis factor (TNF)α, IL-15 and macrophage inflammatory protein (MIP)-1β, and the concentrations of IL-8 and MIP-1α were below detection limits.
- 4The results suggest that very early events in exercise trigger the release of IL-6, and that the cytokine response to exercise has similarities to that observed after trauma.