Mesenteric, coeliac and splanchnic blood flow in humans during exercise
Article first published online: 22 SEP 2004
The Journal of Physiology
Volume 513, Issue 3, pages 907–913, December 1998
How to Cite
Perko, M. J., Nielsen, H. B., Skak, C., Clemmesen, J. O., Schroeder, T. V. and Secher, N. H. (1998), Mesenteric, coeliac and splanchnic blood flow in humans during exercise. The Journal of Physiology, 513: 907–913. doi: 10.1111/j.1469-7793.1998.907ba.x
- Issue published online: 22 SEP 2004
- Article first published online: 22 SEP 2004
- (Received 31 March 1998; accepted after revision 14 September 1998)
- 1Exercise reduces splanchnic blood flow, but the mesenteric contribution to this response is uncertain.
- 2In nineteen humans, superior mesenteric and coeliac artery flows were determined by duplex ultrasonography during fasting and postprandial submaximal cycling and compared with the splanchnic blood flow as assessed by the Indocyanine Green dye-elimination technique.
- 3Cycling increased arterial pressure, heart rate and cardiac output, while it reduced total vascular resistance. These responses were not altered in the postprandial state. During fasting, cycling increased mesenteric, coeliac and splanchnic resistances by 76, 165 and 126%, respectively, and it reduced corresponding blood flows by 32, 50 and 43% (by 0.18 ± 0.04, 0.42 ± 0.03 and 0.60 ± 0.04 l min−1). Postprandially, mesenteric and splanchnic vascular resistances decreased, thereby elevating regional blood flow, while the coeliac circulation was not influenced. Postprandial cycling did not influence the mesenteric resistance significantly, but its blood flow decreased by 22% (0.46 ± 0.28 l min−1). Coeliac and splanchnic resistance increased by 150 and 63%, respectively, and the corresponding regional blood flow decreased by 51 and 31% (0.49 ± 0.07 and 0.96 ± 0.28 l min−1). Splanchnic blood flow values assessed by duplex ultrasound and by dye-elimination techniques were correlated (r= 0.70; P < 0.01).
- 4During submaximal exercise in humans, splanchnic resistance increases and blood flow is reduced following a 50% reduction in the hepato-splenic and a 25% reduction in the mesenteric blood flow.