Receptors, gephyrin and gephyrin-associated proteins: novel insights into the assembly of inhibitory postsynaptic membrane specializations

Authors

  • Matthias Kneussel,

    1. Department of Neurochemistry, Max Planck Institute for Brain Research, Deutschordenstrasse 46, D-60528 Frankfurt/Main, Germany
    Search for more papers by this author
  • Heinrich Betz

    Corresponding author
    1. Department of Neurochemistry, Max Planck Institute for Brain Research, Deutschordenstrasse 46, D-60528 Frankfurt/Main, Germany
    • Corresponding author
      H. Betz: Max-Planck-Institut für Himforschung, Deutschordenstrasse 46, D-60528 Frankfurt/Main, Germany., Email: betz@mpih-frankfurt.mpg.de

    Search for more papers by this author

Abstract

The synaptic localization of ion channel receptors is essential for efficient synaptic trans-mission and the precise regulation of diverse neuronal functions, such as signal integration and synaptic plasticity. Emerging evidence points to an important role of cytoskeleton-associated proteins that assemble receptors and components of the subsynaptic machinery at postsynaptic membrane specializations. This article reviews interactions of inhibitory postsynaptic neurotransmitter receptors with the receptor anchoring protein gephyrin and intracellular components involved in downstream signalling and/or control of signal transduction processes. The presently available data suggest a central synaptic organizer function for gephyrin in inhibitory postsynaptic membrane assembly and stabilization.

Ancillary