SEARCH

SEARCH BY CITATION

  • Akira, S., Taga, T. & Kishimoto, T. (1993). Interleukin-6 in biology and medicine. Advances in Immunology 54, 178.
  • Austin, L., Bower, J., Kurek, J. & Vakakis, N. (1992). Effects of leukaemia inhibitory factor and other cytokines on murine and human myoblast proliferation. Journal of the Neurological Sciences 112, 185191.
  • Austin, L. & Burgess, A. W. (1991). Stimulation of myoblast proliferation in culture by leukaemia inhibitory factor and other cytokines. Journal of the Neurological Sciences 101, 193197.
  • Bartoccioni, E., Michaelis, D. & Hohlfeld, R. (1994). Constitutive and cytokine-induced production of interleukin-6 by human myoblasts. Immunology Letters 42, 135138.
  • Bruunsgaard, H., Andersen-Ranberg, K., Jeune, B., Pedersen, A. N., Skinhoj, P. & Pedersen, B. K. (1999). A high plasma concentration of TNF-alpha is associated with dementia in centenarians. Journals of Gerontology 54A, 357364.
  • Bruunsgaard, H., Galbo, H., Halkjaer-Kristensen, J., Johansen, T. L., MacLean, D. A. & Pedersen, B. K. (1997). Exercise-induced increase in serum interleukin-6 in humans is related to muscle damage. Journal of Physiology 499, 833841.
  • Bruunsgaard, H., Pedersen A. N., Schroll, M., Skinhoj, P. & Pedersen, B. K. (2000a). TNF-α, leptin, and lymphocyte function in human aging. Life Sciences 67, 27212731.
  • Bruunsgaard, H., Skinhoj, P., Pedersen, A. N., Schroll, M. & Pedersen, B. K. (2000b). Ageing, tumour necrosis factor-α (TNF-α) and atherosclerosis. Clinical and Experimental Immunology 121, 255260.
  • Cantini, M., Massimino, M. L., Rapizzi, E., Rossini, K., Catani, C., Dalla, L. L. & Carraro, U. (1995). Human satellite cell proliferation in vitro is regulated by autocrine secretion of IL-6 stimulated by a soluble factor(s) released by activated monocytes. Biochemical and Biophysical Research Communications 216, 4953.
  • Castell, L. M., Poortmans, J. R., Leclercq, R., Brasseur, M., Duchateau, J. & Newsholme, E. A. (1997). Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation. European Journal of Applied Physiology and Occupational Physiology 75, 4753.
  • Cohen, T., Nahari, D., Cerem, L. W., Neufeld, G. & Levi, B. Z. (1996). Interleukin 6 induces the expression of vascular endothelial growth factor. Journal of Biological Chemistry 271, 736741.
  • Croisier, J. L., Camus, G., Venneman, I., Deby-Dupont, G., Juchmes-Ferir, A., Lamy, M., Crielaard, J. M., Deby, C. & Duchateau, J. (1999). Effects of training on exercise-induced muscle damage and interleukin 6 production. Muscle and Nerve 22, 208212.
  • Croucher, P. I., Wang, F. & Hargreaves, P. G. (1999). Interleukin-6 receptor shedding: a possible role for members of the ADAM family. Biochemical Society Transactions 27, 224228.
  • Cryer, P. E. (1993). Glucose counterregulation: prevention and correction of hypoglycemia in humans. American Journal of Physiology 264, E149155.
  • De Benedetti, F., Alonzi, T., Moretta, A., Lazzaro, D., Costa, P., Poli, V., Martini, A., Ciliberto, G. & Fattori, E. (1997). Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation. Journal of Clinical Investigation 99, 643650.
  • DeRijk, R. H., Boelen, A., Tilders, F. J. & Berkenbosch, F. (1994). Induction of plasma interleukin-6 by circulating adrenaline in the rat. Psychoneuroendocrinology 19, 155163.
  • De Rossi, M., Bernasconi, P., Baggi, F., e Waal, M. R. & Mantegazza, R. (2000). Cytokines and chemokines are both expressed by human myoblasts: possible relevance for the immune pathogenesis of muscle inflammation. International Immunology 12, 13291335.
  • Drenth, J. P., n Uum, S. H., n Deuren, M., Pesman, G. J., van der ven Jongekrug, J. & van der Meer, J. W. (1995). Endurance run increases circulating IL-6 and IL-1ra but downregulates ex vivo TNF-α and IL-1β production. Journal of Applied Physiology 79, 14971503.
  • Fernandez-Real, J. M., Broch, M., Vendrell, J., Gutierrez, C., Casamitjana, R., Pugeat, M., Richart, C. & Ricart, W. (2000). Interleukin-6 gene polymorphism and insulin sensitivity. Diabetes 49, 517520.
  • Franchimont, N., Gangji, V., Durant, D. & Canalis, E. (1997). Interleukin-6 with its soluble receptor enhances the expression of insulin-like growth factor-I in osteoblasts. Endocrinology 138, 52485255.
  • Fried, S. K., Bunkin, D. A. & Greenberg, A. S. (1998). Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. Journal of Clinical Endocrinology and Metabolism 83, 847850.
  • Gadient, R. A. & Patterson, P. H. (1999). Leukemia inhibitory factor, interleukin 6, and other cytokines using the GP130 transducing receptor: roles in inflammation and injury. Stem Cells 17, 127137.
  • Gleeson, M. & Bishop, N. C. (2000). Special feature for the Olympics: effects of exercise on the immune system: modification of immune responses to exercise by carbohydrate, glutamine and anti-oxidant supplements. Immunology and Cell Biology 78, 554561.
  • Gustafsson, T., Puntschart, A., Kaijser, L., Jansson, E. & Sundberg, C. J. (1999). Exercise-induced expression of angiogenesis-related transcription and growth factors in human skeletal muscle. American Journal of Physiology 276, H679685.
  • Haegeman, G., Content, J., Volckaert, G., Derynck, R., Tavernier, J. & Fiers, W. (1986). Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts. European Journal of Biochemistry 159, 625632.
  • Hardin, J., Kroeker, K., Chung, B. & Gall, D. G. (2000). Effect of proinflammatory interleukins on jejunal nutrient transport. Gut 47, 184191.
  • Hellsten, Y., Frandsen, U., øRthenblad, N., Sjjødinoslash;din, N. & Richter, E. A. (1997). Xanthine oxidase in human skeletal muscle following eccentric exercise: a role in inflammation. Journal of Physiology 498, 239248.
  • Hibi, M., Murakami, M., Saito, M., Hirano, T., Taga, T. & Kishimoto, T. (1990). Molecular cloning and expression of an IL-6 signal transducer, gp 130. Cell 63, 11491157.
  • Hibi, M., Nakajima, K. & Hirano, T. (1996). IL-6 cytokine family and signal transduction: a model of the cytokine system. Journal of Molecular Medicine 74, 112.
  • Hirano, T., Matsuda, T. & Nakajima, K. (1994). Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily. Stem Cells 12, 262277.
  • Hirano, T., Nakajima, K. & Hibi, M. (1997). Signaling mechanisms through gp130: a model of the cytokine system. Cytokine and Growth Factor Reviews 8, 241252.
  • Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S., Nakajima, K., Koyama, K., Iwamatsu, A. et al. (1986). Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324, 7376.
  • Hotamisligil, G. S. (1999). The role of TNFα and TNF receptors in obesity and insulin resistance. Journal of Internal Medecine 245, 621625.
  • Houssiau, F. A., Coulie, P. G., Olive, D. & Van Snick, J. (1988). Synergistic activation of human T cells by interleukin 1 and interleukin 6. European Journal of Immunology 18, 653656.
  • Howlett, K., Febbraio, M. & Hargreaves, M. (1999). Glucose production during strenuous exercise in humans: role of epinephrine. American Journal of Physiology 276, E11301135.
  • Jonsdottir, I. H., Schjerling, P., Ostrowski, K., Asp, S., Richter, E. A. & Pedersen, B. K. (2000). Muscle contractions induce interleukin-6 mRNA production in rat skeletal muscles. Journal of Physiology 528, 157163.
  • Kami, K. & Senba, E. (1998). Localization of leukemia inhibitory factor and interleukin-6 messenger ribonucleic acids in regenerating rat skeletal muscle. Muscle and Nerve 21, 819822.
  • Kanemaki, T., Kitade, H., Kaibori, M., Sakitani, K., Hiramatsu, Y., Kamiyama, Y., Ito, S. & Okumura, T. (1998). Interleukin 1β and interleukin 6, but not tumor necrosis factor α, inhibit insulin-stimulated glycogen synthesis in rat hepatocytes. Hepatology 27, 12961303.
  • Keller, C., Steensberg, A., Pilegaard, H., Osada, T., Saltin, B., Pedersen, B. K. & Neufer, P. D. (2001). Transcriptional activation of the IL-6 gene in human contracting skeletal muscle – influence of muscle glycogen content. FASEB Journal (in the Press).
  • Kjaer, M. (2001). Hepatic fuel metabolism during exercise. In Exercise Metabolism, ed. Hargreaves, M., pp. 7398. Human Kinetics, Champaign , IL , USA .
  • Klausen, T., Olsen, N. V., Poulsen, T. D., Richalet, J. P. & Pedersen, B. K. (1997). Hypoxemia increases serum interleukin-6 in humans. European Journal of Applied Physiology and Occupational Physiology 76, 480482.
  • Klouche, M., Bhakdi, S., Hemmes, M. & Rose-John, S. (1999). Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. Journal of Immunology 163, 45834589.
  • Makino, T., Noguchi, Y., Yoshikawa, T., Doi, C. & Nomura, K. (1998). Circulating interleukin 6 concentrations and insulin resistance in patients with cancer. British Journal of Surgery 85, 16581662.
  • Mantzoros, C. S., Moschos, S., Avramopoulos, I., Kaklamani, V., Liolios, A., Doulgerakis, D. E., Griveas, I., Katsilambros, N. & Flier, J. S. (1997). Leptin concentrations in relation to body mass index and the tumor necrosis factor-α system in humans. Journal of Clinical Endocrinology and Metabolism 82, 34083413.
  • May, L. T., Helfgott, D. C. & Sehgal, P. B. (1986). Anti-β-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the β2 interferon involved. Proceedings of the National Academy of Sciences of the USA 83, 89578961.
  • Mohamed-Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., Klein, S. & Coppack, C. (1997). Subcutaneous adipose tissue releases interleukin-6, but not tumour necrosis factor-α, in vivo. Journal of Clinical Endocrinology and Metabolism 82, 41964200.
  • Moldoveanu, A. I., Shephard, R. J. & Shek, P. N. (2000). Exercise elevates plasma levels but not gene expression of IL-1β, IL-6, and TNF-α in blood mononuclear cells. Journal of Applied Physiology 89, 14991504.
  • Muraguchi, A., Hirano, T., Tang, B., Matsuda, T., Horii, Y., Nakajima, K. & Kishimoto, T. (1988). The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. Journal of Experimental Medicine 167, 332344.
  • Nehlsen-Cannarella, S. L., Fagoaga, O. R., Nieman, D. C., Henson, D. A., Butterworth, D. E., Schmitt, R. L., Bailey, E. M., Warren, B. J., Utter, A. & Davis, J. M. (1997). Carbohydrate and the cytokine response to 2. 5 hours of running. Journal of Applied Physiology 82, 16621667.
  • Nielsen, H. B., Secher, N. H., Christensen, N. J. & Pedersen, B. K. (1996). Lymphocytes and NK cell activity during repeated bouts of maximal exercise. American Journal of Physiology 271, R222227.
  • Nieman, D. C., Nehlsen-Cannarella, S. L., Fagoaga, O. R., Henson, D. A., Utter, A., Davis, J. M., Williams, F. & Butterworth, D. E. (1998). Influence of mode and carbohydrate on the cytokine response to heavy exertion. Medecine and Science in Sports and Exercise 30, 671678.
  • Nonogaki, K., Fuller, G. M., Fuentes, N. L., Moser, A. H., Staprans, I., Grunfeld, C. & Feingold, K. R. (1995). Interleukin-6 stimulates hepatic triglyceride secretion in rats. Endocrinology 136, 21432149.
  • Northoff, H. & Berg, A. (1991). Immunologic mediators as parameters of the reaction to strenuous exercise. International Journal of Sports Medicine 12, S915.
  • Okazaki, S., Kawai, H., Arii, Y., Yamaguchi, H. & Saito, S. (1996). Effects of calcitonin gene-related peptide and interleukin 6 on myoblast differentiation. Cell Proliferation 29, 173182.
  • Ostrowski, K., Hermann, C., Bangash, A., Schjerling, P., Nielsen, J. N. & Pedersen, B. K. (1998a). A trauma-like elevation in plasma cytokines in humans in response to treadmill running. Journal of Physiology 508, 949953.
  • Ostrowski, K., Rohde, T., Asp, S., Schjerling, P. & Pedersen, B. K. (1999). Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans. Journal of Physiology 515, 287291.
  • Ostrowski, K., Rohde, T., Asp, S., Schjerling, P. & Pedersen, B. K. (2001). Chemokines are elevated in plasma after strenuous exercise. European Journal of Applied Physiology 84, 244245.
  • Ostrowski, K., Rohde, T., Zacho, M., Asp, S. & Pedersen, B. K. (1998b). Evidence that IL-6 is produced in skeletal muscle during intense long-term muscle activity. Journal of Physiology 508, 949953.
  • Ostrowski, K., Schjerling, P. & Pedersen, B. K. (2000). Physical activity and plasma interleukin-6 in humans – effect of intensity of exercise. European Journal of Applied Physiology 83, 512515.
  • Pedersen, B. K. & Hoffman-Goetz, L. (2000). Exercise and the immune system: regulation, integration and adaptation. Physiological Reviews 80, 10551081.
  • Pedersen, B. K., Steensberg, A. & Schjerling, P. (2001). Exercise and interleukin-6. Current Opinion in Hematology 8, 137141.
  • Petersen, E. W., Ostrowski, K., Ibfelt, T., Richelle, M., Offord, E., Halkjaer-Kristensen, J. & Pedersen, B. K. (2001). Effect of vitamin supplementation on the cytokine response and on muscle damage following strenuous exercise. American Journal of Physiology 280, C15701575.
  • Pickup, J. C., Chusney, G. D., Thomas, S. M. & Burt, D. (2000). Plasma interleukin-6, tumour necrosis factor α and blood cytokine production in type 2 diabetes. Life Sciences 67, 291300.
  • Rehman, J., Mills, P. J., Carter, S. M., Chou, J., Thomas, J. & Maisel, A. S. (1997). Dynamic exercise leads to an increase in circulating ICAM-1: further evidence for adrenergic modulation of cell adhesion. Brain, Behavior, and Immunity 11, 343351.
  • Ridker, P. M., Hennekens, C. H., Buring, J. E. & Rifai, N. (2000a). C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. New England Journal of Medicine 342, 836843.
  • Ridker, P. M., Rifai, N., Stampfer, M. J. & Hennekens, C. H. (2000b). Plasma concentration of interleukin-6 and the risk of future mycocardial infarction among apparently healthy men. Circulation 101, 17671772.
  • Rohde, T., MacLean, D. A., Richter, E. A., Kiens, B. & Pedersen, B. K. (1997). Prolonged submaximal eccentric exercise is associated with increased levels of plasma IL-6. American Journal of Physiology 273, E8591.
  • Saito, H., Patterson, C., Hu, Z., Runge, M. S., Tipnis, U., Sinha, M. & Papaconstantinou, J. (2000). Expression and self-regulatory function of cardiac interleukin-6 during endotoxemia. American Journal of Physiology – Heart and Circulatory Physiology 279, H22412248.
  • Saito, M., Yoshida, K., Hibi, M., Taga, T. & Kishimoto, T. (1992). Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo. Journal of Immunology 148, 40664071.
  • Schjerling, P., Ostrowski, K., Asp, S. & Pedersen, B. K. (2001). Exercise induces interleukin-6 and interleukin-1β expression within human skeletal muscle. Journal of Physiology 531.P, 5960P.
  • Sigal, R. J., Fisher, S. J., Manzon, A., Morais, J. A., Halter, J. B., Vranic, M. & Marliss, E. B. (2000). Glucoregulation during and after intense exercise: effects of α-adrenergic blockade. Metabolism 49, 386394.
  • Sigal, R. J., Purdon, C., Bilinski, D., Vranic, M., Halter, J. B. & Marliss, E. B. (1994). Glucoregulation during and after intense exercise: effects of β-blockade. Journal of Clinical Endocrinology and Metabolism 78, 359366.
  • Sprenger, H., Jacobs, C., Nain, M., Gressner, A. M., Prinz, H., Wesemann, W. & Gemsa, D. (1992). Enhanced release of cytokines, interleukin-2 receptors, and neopterin after long-distance running. Clinical Immunology and Immunopathology 63, 188195.
  • Starkie, R. L., Angus, D. J., Rolland, J., Hargreaves, M. & Febbraio, M. A. (2000). Effect of prolonged submaximal exercise and carbohydrate ingestion on monocyte intracellular cytokine production in humans. Journal of Physiology 528, 647655.
  • Starkie, R. L., Arkinstall, M. J., Koukoulas, I., Hawley, J. A. & Febbraio, M. A. (2001a). Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans. Journal of Physiology 533, 585591.
  • Starkie, R. L., Rolland, J., Angus, D. J., Aanderson, M. J. & Febbraio, M. A. (2001b). Circulating monocyes are not the source of elevations in plasma IL-6 and TNF-α levels after prolonged running. American Journal of Physiology – Cell Physiology 280, C769774.
  • Steensberg, A., Febbraio, M. A., Osada, T., Schjerling, P., n Hall, G., Saltin, B. & Pedersen, B. K. (2001a). Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content. Journal of Physiology (in the Press).
  • Steensberg, A., Toft, A. D., Schjerling, P., Halkjaer-Kristensen, J. & Pedersen, B. K. (2001b). Plasma interleukin-6 during strenuous exercise: role of epinephrine. American Journal of Physiology – Cell Physiology 281, C10011004.
  • Steensberg, A., n Hall, G., Osada, T., Sacchetti, M., Saltin, B. & Pedersen, B. K. (2000). Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. Journal of Physiology 529, 237242.
  • Steensberg, A., Vissing, J. & Pedersen, B. K. (2001c). Lack of IL-6 production during exercise in patients with mitochondrial myopathy. European Journal of Applied Physiology 84, 155157.
  • Stouthard, J. M., Oude Elferink, R. P. & Sauerwein, H. P. (1996). Interleukin-6 enhances glucose transport in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications 220, 241245.
  • Stouthard, J. M., Romijn, J. A., Vander Poll, T., Endert, E., Klain, S., Bakker, P. J., Veenhof, C. H. & Sauerwein, H. P. (1995). Endocrinologic and metabolic effects of interleukin-6 in humans. American Journal of Physiology 268, E813819.
  • Sundgren-Andersson, A. K., Ostlund, P. & Bartfai, T. (1998). IL-6 is essential in TNF-alpha-induced fever. American Journal of Physiology 275, R20282034.
  • Takai, Y., Wong, G. G., Clark, S. C., Burakoff, S. J. & Herrmann, S. H. (1988). B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes. Journal of Immunology 140, 508512.
  • Toft, A. D., Ostrowski, K., Asp, S., Mølleroslash;ller, K., Iversen, S., Hermann, C., Søndergaardoslash;ndergaard, S. R. & Pedersen, B. K. (2000). The effects of n-3 PUFA on the cytokine response to strenuous execise. Journal of Applied Physiology 89, 24012405.
  • Tsigos, C., Kyrou, I., Chala, E., Tsapogas, P., Stavridis, J. C., Raptis, S. A. & Katsilambros, N. (1999). Circulating tumour necrosis factor α concentrations are higher in abdominal versus peripheral obesity. Metabolism 48, 13321335.
  • Tsigos, C., Papanicolaou, D. A., Kyrou, I., Defensor, R., Mitsiadis, C. S. & Chrousos, G. P. (1997). Dose-dependent effects of recombinant human interleukin-6 on glucose regulation. Journal of Clinical Endocrinology and Metabolism 82, 41674170.
  • Tsujinaka, T., Ebisui, C., Fujita, J., Kishibuchi, M., Morimoto, T., Ogawa, A., Katsume, A., Ohsugi, Y., Kominami, E. & Monden, M. (1995). Muscle undergoes atrophy in association with increase of lysosomal cathepsin activity in interleukin-6 transgenic mouse. Biochemical and Biophysical Research Communications 207, 168174.
  • Tsujinaka, T., Fujita, J., Ebisui, C., Yano, M., Kominami, E., Suzuki, K., Tanaka, K., Katsume, A., Ohsugi, Y., Shiozaki, H. & Monden, M. (1996). Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice. Journal of Clinical Investigation 97, 244249.
  • Ullum, H., Haahr, P. M., Diamant, M., Palmo, J., Halkjaer-Kristensen, J. & Pedersen, B. K. (1994). Bicycle exercise enhances plasma IL-6 but does not change IL-1α, IL-1β, IL-6, or TNF-α pre-mRNA in BMNC. Journal of Applied Physiology 77, 9397.
  • Van Wagoner, N. J. & Benveniste, E. N. (1999). Interleukin-6 expression and regulation in astrocytes. Journal of Neuroimmunology 100, 124139.
  • Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Hopper, K., Lotsikas, A., Lin, H. M., Kales, A. & Chrousos, G. P. (2000). Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia. Journal of Clinical Endocrinology and Metabolism 85, 11511158.
  • Vierck, J., O'Reilly, B., Hossner, K., Antonio, J., Byrne, K., Bucci, L. & Dodson, M. (2000). Satellite cell regulation following myotrauma caused by resistance exercise. Cell Biology International 24, 263272.
  • Yan, S. F., Tritto, I., Pinsky, D., Liao, H., Huang, J., Fuller, G., Brett, J., May, L. & Stern, D. (1995). Induction of interleukin 6 (IL-6) by hypoxia in vascular cells. Central role of the binding site for nuclear factor-IL-6. Journal of Biological Chemistry 270, 1146311471.
  • Yudkin, J. S., Kumari, M., Humphries, S. E. & Mohammed-Ali, V. (2000). Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 148, 209214.
  • Zhang, Y., Pilon, G., Marette, A. & Baracos, V. E. (2000). Cytokines and endotoxin induce cytokine receptors in skeletal muscle. American Journal of Physiology – Endocrinology and Metabolism 279, E196205.
  • Zilberstein, A., Ruggieri, R., Korn, J. H. & Revel, M. (1986). Structure and expression of cDNA and genes for human interferon-β-2, a distinct species inducible by growth-stimulatory cytokines. EMBO Journal 5, 25292537.