1. Osteomalacia, or so-called spontaneous generalised bone-softening, is not a simple decalcification of bone, but a reorganisation of bone as an organ, in which the loss of osseous tissue is not brought about by osteoclasts.
2. From this it is evident that the cell-masses known by the name of “osteoclasts” are not indispensable in the transformation of bone to less specialised tissue.
3. The disease may be infectious in origin. If so, the evidence at our disposal points to the nervous system as the site of infection. The bone-changes appear to be the symptoms consequent on the nervous lesion.