Functional redundancy in the Arabidopsis Cathepsin B gene family contributes to basal defence, the hypersensitive response and senescence
Article first published online: 11 MAY 2009
© The Authors (2009). Journal compilation © New Phytologist (2009)
Volume 183, Issue 2, pages 408–418, July 2009
How to Cite
McLellan, H., Gilroy, E. M., Yun, B.-W., Birch, P. R. J. and Loake, G. J. (2009), Functional redundancy in the Arabidopsis Cathepsin B gene family contributes to basal defence, the hypersensitive response and senescence. New Phytologist, 183: 408–418. doi: 10.1111/j.1469-8137.2009.02865.x
- Issue published online: 25 JUN 2009
- Article first published online: 11 MAY 2009
- Received: 13 March 2009, Accepted: 17 March 2009
- AGI. 2000. Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature 408: 796–815.
- 1949. Copper enzymes in isolated chloroplasts, polyphenoloxidase in Beta vulgaris. Plant Physiology 24: 1–15. .
- 2002. Runaway cell death, but not basal disease resistance, in lsd1 is SA- and NIM1/NPR1-dependent. Plant Journal 29: 381–391. , , , , , .
- 2004. Potato oxysterol binding protein and cathepsin B are rapidly up-regulated in independent defence pathways that distinguish R gene-mediated and field resistances to Phytophthora infestans. Molecular Plant Pathology 5: 45–56. , , , , , , , , , et al .
- 2003. AtCYS1, a cystatin from Arabidopsis thaliana, suppresses hypersensitive cell death. European Journal of Biochemistry 270: 2593–2604. , , , , , , ,
- 2007. Cathepsin-cleaved Bid promotes apoptosis in human neutrophils via oxidative stress-induced lysosomal membrane permeabilization. Journal of Leukocyte Biology 81: 1213–1223. , ,
- 2003. Mechanisms of caspase activation. Current Opinion in Cell Biology 15: 725. , .
- 2008. What happened to plant caspases? Journal of Experimental Botany 59: 491–499. , , ,
- 1997. The cpr5 mutant of Arabidopsis expresses both NPR1-dependent and NPR1-independent resistance. Plant Cell 9: 1573–1584. , , , ,
- 1997. The molecular biology of leaf senescence. Journal of Experimental Botany 48: 181–199.
- 2005. Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant Journal 42: 567–585. , , , , , , , , , et al .
- 1998. Differential expression of a senescence-enhanced metallothionein gene in Arabidopsis in response to isolates of Peronospora parasitica and Pseudomonas syringae. Plant Journal 16: 209–221. , , , , , , ,
- 1994. Characterization of an Arabidopsis mutant that is nonresponsive to inducers of systemic acquired resistance. Plant Cell 6: 1583–1592. , , ,
- 2004. A plant caspase-like protease activated during the hypersensitive response. Plant Cell 16: 157–171. , , , , , , , , .
- 1987. Single step method of RNA isolation by acid guanidinium thiocyanate phenol chloroform extraction. Analytical Biochemistry 162: 156. ,
- 2003. Cytological and pharmacological evidence that biotrophic fungi trigger different cell death execution processes in host and nonhost cells during the hypersensitive response. Physiological and Molecular Plant Pathology 62: 265. , .
- 2004. Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. Journal of Biological Chemistry 279: 3578–3587. , , , , , , ,
- 1998. Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. Plant Journal 16: 735–743. , .
- 2004. Purification and characterization of serine proteases that exhibit caspase-like activity and are associated with programmed cell death in Avena sativa. Plant Cell 16: 857–873. , .
- 1998. Activation of cysteine proteases in cowpea plants during the hypersensitive response – a form of programmed cell death. Experimental Cell Research 245: 389–399. , , .
- 1996. Death don't have no mercy: cell death programs in plant–microbe interactions. Plant Cell 8: 1793–1807. , , .
- 1998. Caspases and programmed cell death in the hypersensitive response of plants to pathogens. Current Biology 8: 1129–1132. ,
- 1999. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annual Review of Biochemistry 68: 383–424. , , .
- 2004. Programmed cell death in response to abiotic stress. In: GrayJ, ed. Programmed cell death in plants. Oxford, UK: Blackwell, 194–212.
- 2005. A central role for S-nitrosothiols in plant disease resistance. Proceedings of the National Academy of Science, USA 102: 8054–8059. , , , , , .
- 2001. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. Journal of Cell Biology 153: 999–1010. , , , , , , , ,
- 2005. Natural variation in the Arabidopsis response to the avirulence gene hopPsyA uncouples the HR from disease resistance. Molecular Plant–Microbe Interactions 18: 1054–1060.
- 1999. The Arabidopsis RPS4 bacterial-resistance gene is a member of the TIR-NBS-LRR family of disease-resistance genes. Plant Journal 20: 265–277. , , .
- 2007. Involvement of cathepsin B in the plant disease resistance hypersensitive response. Plant Journal 52: 1–13. , , , , , , , , , et al .
- 2002. Mutation of the matrix metalloproteinase At2-MMP inhibits growth and causes late flowering and early senescence in Arabidopsis. Journal of Biological Chemistry 277: 5541–5547. , ,
- 1996. Expression of the Pseudomonas syringae avirulence protein AvrB in plant cells alleviates its dependence on the hypersensitive response and pathogenicity (Hrp) secretion system in eliciting genotype-specific hypersensitive cell death. Plant Cell 8: 1095–1105. , , , , ,
- 2000. The RPM1 plant disease resistance gene facilitates a rapid and sustained increase in cytosolic calcium that is necessary for the oxidative burst and hypersensitive cell death. Plant Journal 23: 441–450. , , , , ,
- 2001. Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications. American Journal of Pathology 159: 2045–2054. , , , .
- 2004. Transcriptome of Arabidopsis leaf senescence. Plant, Cell & Environment 27: 521–549. , ,
- 2007. Expression of a metacaspase gene of Nicotiana benthamiana after inoculation with Colletotrichum destructivum or Pseudomonas syringae pv. tomato, and the effect of silencing the gene on the host response. Plant Cell Reports 26: 1879. , ,
- 2006. A cellular suicide strategy of plants: vacuole-mediated cell death. Apoptosis 11: 905. , , ,
- 2004. A plant vacuolar protease, VPE, mediates virus-induced hypersensitive cell death. Science 305: 855–858. , , , , , , ,
- 2008. Metacaspase-8 modulates programmed cell death induced by ultraviolet light and H2O2 in Arabidopsis. Journal of Biological Chemistry 283: 774–783. , , , , , , ,
- 1993. Pseudomonas syringae pv. syringae harpinPss: a protein that is secreted via the Hrp pathway and elicits the hypersensitive response in plants. Cell 73: 1255–1266. , ,
- 2001. Networking senescence-regulating pathways by using Arabidopsis enhancer trap lines. Plant Physiology 126: 707–716. , , , , ,
- 1998. Apoptosis, programmed cell death and the hypersensitive response. European Journal of Plant Pathology 104: 117–124. .
- 2000. Hypersensitive response-related death. Plant Molecular Biology 44: 321–334. .
- 2000. pGreen: a versatile and flexible binary Ti vector for Agrobacterium-mediated plant transformation. Plant Molecular Biology 42: 819–832. , , , , .
- 2003. A tomato metacaspase gene is upregulated during programmed cell death in Botrytis cinerea-infected leaves. Planta 217: 517–522. , , .
- 2006. bZIP10-LSD1 antagonism modulates basal defense and cell death in Arabidopsis following infection. EMBO Journal 25: 4400–4411. , , , , , , , , , et al .
- 2002. History of the events leading to the formulation of the apoptosis concept. Toxicology 471: 181–182. .
- 2007. Inhibition of Agrobacterium-induced cell death by antiapoptotic gene expression leads to very high transformation efficiency of banana. Molecular Plant–Microbe Interactions 20: 1048–1054. , , , , .
- 1954. Two simple media for the demonstration of phycocyanin and fluorescin. Journal of Laboratory and Clinical Medicine 44: 301–307. , , .
- 2001. Microglial secreted cathepsin B induces neuronal apoptosis. Journal of neurochemistry 76: 1475–1484. , .
- 2007. Infection of tobacco with different Pseudomonas syringae pathovars leads to distinct morphotypes of programmed cell death. Plant Journal 50: 253–264. , , , , ,
- 2003. Enhancement of virus-induced gene silencing through viral-based production of inverted-repeats. Plant Journal 34: 543–553. , ,
- 2001. Four deaths and a funeral: from caspases to alternative mechanisms. Nature Reviews. Molecular Cell Biology 2: 589–598. ,
- 1994. Molecular analysis of natural leaf senescence in Arabidopsis thaliana. Physiologia Plantarum 92: 322–328. , , , .
- 2003. Lesion mimic mutants: keys for deciphering cell death and defense pathways in plants? Trends in Plant Science 8: 263–271. , , ,
- 2004. Programmed cell death in xylem development. In: GrayJ, ed. Programmed cell death in plants. Oxford, UK: Blackwell Publishing, 131–154. ,
- 1997. Identification of three genetic loci controlling leaf senescence in Arabidopsis thaliana. Plant Journal 12: 527–535. , , , , , .
- 2004. Programmed cell death in plant senescence. In: GrayJ, ed. Programmed cell death in plants. Oxford, UK: Blackwell, 155–193. ,
- 2005. Senescence-associated vacuoles with intense proteolytic activity develop in leaves of Arabidopsis and soybean. Plant Journal 41: 831–844. , , , , , , .
- 2005. Inverted repeat PCR for the rapid assembly of constructs to induce RNA interference. Plant & Cell Physiology 46: 1872–1878. , , , , .
- 1999. Markers for hypersensitive response and senescence show distinct patterns of expression. Plant Molecular Biology 39: 1243–1255. , , , ,
- 1998. Activation of hsr203, a plant gene expressed during incompatible plant–pathogen interactions, is correlated with programmed cell death. Molecular Plant–Microbe Interactions 11: 544–554. , , , ,
- 2001. Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L. Biological Chemistry 382: 735–741. , , ,
- 2004. Programmed cell death events during reproductive development. In: GrayJ, ed. Programmed cell death in plants. Oxford, UK: Blackwell, 71–105. .
- 1989. Molecular cloning: a laboratory manual. Cold Spring Harbor, NY, USA: Cold Spring Harbor Laboratory Press. , ,
- 1999. The involvement of cysteine proteases and protease inhibitor genes in the regulation of programmed cell death in plants. Plant Cell 11: 431–444. , , , ,
- 2002. Arabidopsis gp91phox homologues AtrbohD and AtrbohF are required for accumulation of reactive oxygen intermediates in the plant defense response. Proceedings of the National Academy of Science, USA 99: 517–522. , , .
- 2007. Protease signalling in cell death: caspases versus cysteine cathepsins. FEBS Letters 581: 2761–2767. ,
- 2000. Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Molecular Cell 6: 961. , , , , , , .
- 2007. Proteasome function is required for activation of programmed cell death in heat shocked tobacco Bright-Yellow 2 cells. FEBS Letters 581: 917. , , , , , , ,
- 1998. Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity. FEBS Letters 438: 150–158. , , , , , , , , ,
- 2007. Dual contrasting roles of cysteine cathepsins in cancer progression: apoptosis versus tumour invasion. Biochimie 90: 380–386. ,
- 1998. A comparison of the expression patterns of several senescence-associated genes in response to stress and hormone treatment. Plant Molecular Biology 37: 455–469. , , , .
- 2006. Computational estimation and verification of off-target silencing during post-transcriptional gene silencing in plants. Plant Physiology 142: 429–440. , , , , .
- 1998. Gene-for-gene disease resistance without the hypersensitive response in Arabidopsis dnd1 mutant. Proceedings of the National Academy of Science, USA 95: 7819–7824. , , .
- 2003. Loss of actin cytoskeletal function and EDS1 activity, in combination, severely compromises nonhost resistance in Arabidopsis against wheat powdery mildew. Plant Journal 34: 768–777. , , , , , , .
- 2005. Gene-expression analysis and network discovery using Genevestigator. Trends in Plant Science 10: 407. , ,
- 2004. Genevestigator: Arabidopsis microarray database and analysis toolbox. Plant Physiology 136: 2621–2632. , , ,