Efficacy of very high dose steroid treatment in a case of Landau-Kleffnersyndrome
Article first published online: 13 FEB 2007
Developmental Medicine & Child Neurology
Volume 48, Issue 9, pages 766–769, September 2006
How to Cite
Gallagher, S., Weiss, S., E Harman, K. and Menascu, S. (2006), Efficacy of very high dose steroid treatment in a case of Landau-Kleffnersyndrome. Developmental Medicine & Child Neurology, 48: 766–769. doi: 10.1111/j.1469-8749.2006.tb01364.x
- Issue published online: 13 FEB 2007
- Article first published online: 13 FEB 2007
- Accepted for publication 17th January 2006.
Landau-Kleffner syndrome (LKS) is an acquired childhood aphasia associated with paroxysmal bitemporal electroencephalogram (EEG) abnormalities and, sometimes, clinical seizures. We report the case of a female aged 5 years 6 months who presented clinically with apparent hearing loss, deterioration in speech, and seizure activity over 12 days. The female had previous detailed speech/language assessments at 3 to 4 years of age due to articulation delay. LKS was diagnosed on EEG with bitemporal spike and wave activity during sleep. The patient was treated with high dose prednisolone 3mg/kg/day, intensive speech/language therapy, and followed a modified educational program. We recorded a marked regression in receptive and expressive language skills, as well as her speech, language, and cognitive profiles before and during treatment with prednisolone, during an 18-month follow-up period. The patient demonstrated an excellent clinical response highlighting the importance of a multidisciplinary approach to management of LKS.