Recurrent optic neuritis associated with Chlamydia pneumoniae infection of the central nervous system
Article first published online: 13 FEB 2007
Developmental Medicine & Child Neurology
Volume 48, Issue 9, pages 770–772, September 2006
How to Cite
Pohl, D., Rostasy, K., Gieffers, J., Maass, M. and Hanefeld, F. (2006), Recurrent optic neuritis associated with Chlamydia pneumoniae infection of the central nervous system. Developmental Medicine & Child Neurology, 48: 770–772. doi: 10.1111/j.1469-8749.2006.tb01365.x
- Issue published online: 13 FEB 2007
- Article first published online: 13 FEB 2007
- Accepted for publication 12th December 2005.
It has been suggested that Chlamydia pneumoniae (C. pneumoniae) is involved in the pathogenesis of diverse diseases of the central nervous system (CNS), including multiple sclerosis. We report the case of a 12-year-old male with isolated recurrent optic neuritis and an associated CNS infection with C. pneumoniae. The patient presented with three attacks of optic neuritis within 5 months. A positive polymerase chain reaction for C. pneumoniae in the cerebrospinal fluid led to the diagnosis of a CNS infection with C. pneumoniae. After treatment with the antibiotic rifampicin, he experienced no further attacks during the follow-up period of 6 years. These findings suggest the possibility of a C. pneumoniae infection as a contributing factor or even causative event for the development of optic neuritis.