Are amygdalar volume alterations in children with Tourette syndrome due to ADHD comorbidity?
Version of Record online: 11 JUL 2008
Copyright © 2008 Mac Keith Press
Developmental Medicine & Child Neurology
Volume 50, Issue 7, pages 524–529, July 2008
How to Cite
Ludolph, A. G., Pinkhardt, E. H., Tebartz van Elst, L., Libal, G., Ludolph, A. C., Fegert, J. M. and Kassubek, J. (2008), Are amygdalar volume alterations in children with Tourette syndrome due to ADHD comorbidity?. Developmental Medicine & Child Neurology, 50: 524–529. doi: 10.1111/j.1469-8749.2008.03014.x
- Issue online: 11 JUL 2008
- Version of Record online: 11 JUL 2008
- Accepted for publication 3rd January 2008.
Recent studies have shown that changes in the basal ganglia circuitry and limbic loops may play an important role both in Tourette syndrome (TS) and attention-deficit–hyperactivity disorder (ADHD). This study aimed to investigate in vivo possible morphological alterations of the amygdala as a key component of the limbic system. Amygdalar and total brain volumes were measured in three-dimensional magnetic resonance imaging data sets of 17 male patients with TS (mean age 11y 8mo [SD 2y]; range 9–16y) and 17 age-matched comparison children (mean age 12y 6mo (SD 2y 1mo); range 9–17y) by volume-of-interest-based volumetry. Eight members of the TS group also fulfilled the diagnostic criteria for ADHD. A significant decrease in the left-hemispheric amygdalar volumes and in the proportions of amygdalar to total brain volumes was observed in members of the TS group compared with the comparison group. Amygdalar volumes did not correlate with tic severity, but with behavioural impairment and especially with symptoms of ADHD. The amygdalar volume reduction might be the pathoanatomical correlate of an impaired input of the amygdala to the striatum and frontal cortex. Future studies should investigate if the involvement of the amygdala is due to TS or rather caused by the genetically-linked most frequent comorbidity ADHD.