Acknowledgements This research was supported by a grant for the ASQME project from the Canadian Institutes of Health Research (CIHR; MOP-53258). The OMG study was supported by grants from the CIHR (MT-13476) and the National Center for Medical Rehabilitation Research of the US National Institute of Child Health and Human Development (RO1-HD-34947). Dr Rosenbaum holds a CIHR Canada Research Chair in Childhood Disability and the Scotiabank Chair at the McMaster Child Health Research Institute. Dr Russell holds a Research Scholar award from the Ontario Federation of Cerebral Palsy. The CanChild Centre for Childhood Disability Research is supported by the Ontario Ministry of Health and Long-term Care. We thank the team of ASQME assessors across Ontario who worked to collect these data. Special thanks are owed to Barb Galuppi who coordinated the OMG and ASQME studies and supervised the collection of these data. We are indebted to the children, adolescents, and their families who were involved in these studies and were so willing to share their experiences.
Stability and decline in gross motor function among children and youth with cerebral palsy aged 2 to 21 years
Article first published online: 3 FEB 2009
© The Authors. Journal compilation © Mac Keith Press 2008
Developmental Medicine & Child Neurology
Volume 51, Issue 4, pages 295–302, April 2009
How to Cite
HANNA, S. E., ROSENBAUM, P. L., BARTLETT, D. J., PALISANO, R. J., WALTER, S. D., AVERY, L. and RUSSELL, D. J. (2009), Stability and decline in gross motor function among children and youth with cerebral palsy aged 2 to 21 years. Developmental Medicine & Child Neurology, 51: 295–302. doi: 10.1111/j.1469-8749.2008.03196.x
- Issue published online: 18 MAR 2009
- Article first published online: 3 FEB 2009
- PUBLICATION DATA Accepted for publication 7th September 2008. Published online 3rd February 2009.
This paper reports the construction of gross motor development curves for children and youth with cerebral palsy (CP) in order to assess whether function is lost during adolescence. We followed children previously enrolled in a prospective longitudinal cohort study for an additional 4 years, as they entered adolescence and young adulthood. The resulting longitudinal dataset comprised 3455 observations of 657 children with CP (369 males, 288 females), assessed up to 10 times, at ages ranging from 16 months to 21 years. Motor function was assessed using the 66-item Gross Motor Function Measure (GMFM-66). Participants were classified using the Gross Motor Function Classification System (GMFCS). We assessed the loss of function in adolescence by contrasting a model of function that assumes no loss with a model that allows for a peak and subsequent decline. We found no evidence of functional decline, on average, for children in GMFCS Levels I and II. However, in Levels III, IV, and V, average GMFM-66 was estimated to peak at ages 7 years 11 months, 6 years 11 months, and 6 years 11 months respectively, before declining by 4.7, 7.8, and 6.4 GMFM-66 points, in Levels III, IV, and V respectively, as these adolescents became young adults. We show that these declines are clinically significant.
Cerebral palsy (CP) is a group of disorders affecting development of movement and posture, causing activity limitations attributed to non-progressive disturbances that occur in the developing fetal or infant brain.1 Although non-progression of the underlying neuropathology is a defining feature of the disorder, this does not apply to the clinical manifestations, which are widely believed to change through the lifespan.2 In particular, after developmental gains in childhood,3 persons with CP may decline in gross motor function as they move into adolescence and young adulthood.4 Some studies have documented a reduction in the number of people with CP who walk after age 18.5–7 The timing, scope, and extent of change in gross motor function are not well documented.
Previous research to document declines in gross motor function with age has involved self-reports or chart reviews of changes in ambulation. Bottos et al.5 conducted a chart review and found that 13 of 29 persons with CP who could walk independently before age 18 years lost this capability between the ages of 20 and 40 years. In a survey of 766 Norwegian adults with CP, of the 88% who had previously walked to some degree, 45% reported that their walking ability had deteriorated, whereas 27% said it had improved.6
The largest studies of change in ambulation come from longitudinal data collected by the California Department of Developmental Services.7,8 The Department collects annual assessments across a variety of health and function domains from all persons who receive disability-related services in the state. Day et al.7 conducted a secondary analysis of the resulting data for 7550 children with CP who were first assessed at ages 9 to 12 years, and who were followed for 15 years. They constructed an ordinal assessment of usual mobility, ranging from (1) ‘walks and climbs well’ to (4) ‘does not walk.’ Children who walked unsteadily and sometimes used a wheelchair were most likely to lose ambulatory ability as young adults (34%). Thus, it seems likely that the probability of decrease in mobility depends on the initial degree of mobility limitation.
In contrast to studies that focused on changes in ambulation and wheelchair use, Rosenbaum et al.3 measured gross motor function comprehensively, systematically, and repeatedly, using the standardized and validated Gross Motor Function Measure (GMFM-66) in a large, representative, prospective longitudinal cohort of children with CP who were 12 years of age and younger at enrolment to the study. In this study (the Ontario Motor Growth [OMG] study), nonlinear models of motor development were estimated assuming that children’s GMFM-66 scores rise toward a limit of motor ability, which varies according to their Gross Motor Function Classification System (GMFCS) level.9 This model worked well for characterizing early developmental gains. However, in adolescence and young adulthood, the level of motor performance achieved earlier may not be maintained.
We recently completed a study that followed a sample of the participants in the OMG3 study into adolescence and young adulthood, with continuing longitudinal assessments using GMFCS and GMFM-66. In the current report, we aim to assess the possible loss of gross motor function during adolescence. We do this by contrasting a model of motor function that assumes no loss of function with a model that allows for a peak and subsequent decline. We identify the GMFCS levels in which loss of gross motor function is most likely, and estimate the average age of onset and amount of lost function.
The data for this study were obtained as part of the Adolescent Study of Quality of life, Mobility and Exercise (ASQME). ASQME is a 5-year continuation of the OMG study, which followed a stratified random sample of 657 children with CP from a population-based cohort obtained between 1996 and 2001.3 Sampling and procedures for the OMG study are described in detail elsewhere.3 Both studies were approved by the Research Ethics Board at McMaster University and several community programs. A parent provided informed consent and each adolescent provided informed consent or assent, if possible.
Children with CP and their families were recruited to the OMG study through 19 regional ambulatory children’s rehabilitation centers in the province of Ontario, Canada, beginning in 1996. These centers are publicly funded and each program serves the majority of eligible children with CP in its geographical area. The OMG sample was stratified by GMFCS severity level9 and age. Children completed up to seven assessments during the OMG study (mean=4.0); the children’s ages ranged from 1 year 5 months to 15 years, although 90% of the assessments occurred when children were between 3 years 1 month and 13 years of age. At the completion of that study, all 343 children aged 11 years or older were invited to participate in ASQME. Two hundred and forty-four (71.1%) children and families agreed to participate and 229 (66.8%) completed at least one of four scheduled annual assessments (mean=3.6). For the current report, the OMG and ASQME data were combined to produce a single longitudinal dataset comprising 3455 observations of 657 children with CP, assessed at ages ranging from 16 months to 21 years. The median number of assessments per child in the combined dataset was five, with 9.0% of children completing one or two assessments, 60.7% completing three to six assessments, and 30.3% completing seven to ten assessments. The median age for an assessment was 9 years 5 months, with 50% of assessments done between 6 and 13 years 2 months of age. Males (n=369) comprised 56% of the sample. Of the 640 children for whom topographical distribution was recorded, 98 (15%) had hemiplegia, 217 (34%) had diplegia, 62 (10%) had triplegia, and 268 (41%) had quadriplegia. In the 639 children for whom type of motor impairment was recorded, 500 (78%) spastic, 39 (6%) dyskinetic, 16 (2.5%) ataxic, 26 (4%) hypotonic, and 58 (9%) mixed types were observed.
Measures and Procedure
As described by Rosenbaum et al.,3 children in the OMG study who were under 6 years of age were assessed every 6 months, whereas older children were assessed every 9 to 12 months. The 831 assessments of the 229 adolescents in the ASQME study were made annually. Assessments were completed by physical therapists who were trained to administer the measures and were reassessed annually. They classified children according to the GMFCS9 and administered the GMFM-66.10
Gross motor function classification system
The GMFCS is a five-level system that classifies children with CP in terms of functional ability and limitations.9,11 The GMFCS is straightforward, valid, and reliable for children under 12 years of age.12 Children in Level I walk without limitations in all settings, whereas children in Level V have severe limitations in head and trunk control, and in self-mobility. Although the GMFCS was recorded at each observation, we followed the OMG study3 by using the first available GMFCS classification to stratify analyses. This ensured consistency with our previous research.
Gross motor function measure
Gross motor function was measured using the 66-item GMFM-66, an evaluative instrument for assessing children with CP.10,13–15 The GMFM-66 measures capability, or what a child ‘can do’ in a standardized environment. Items include tasks related to lying and rolling, sitting, crawling and kneeling, standing, walking, running and jumping, with the most difficult items on the scale representing abilities obtained by children developing typically by 5 years of age. Each item is scored by observation on a four-point ordinal scale (0–3). The GMFM-66 was developed using Rasch analysis;14,15 the underlying Rasch model estimates the difficulties of the items,10 so that a child’s total ability score can be easily related to the probability of attaining common motor milestones. Total scores can range from 0 to 100.
Data for each of the five GMFCS levels were analyzed separately. Within GMFCS level, total GMFM-66 scores were analyzed as nonlinear functions of the children’s ages. To evaluate whether the average pattern of change over age included a peak and decline in function, we fitted and contrasted two nonlinear models for each GMFCS level.
The first model (‘Stable Limit’ model) is the same as that used in the OMG study3 to fit motor development curves from ages 2 to 12 years. Children are assumed to start with GMFM-66 scores near 0 as newborn infants, and to acquire gross motor skills rapidly while they are young, with the rate of change slowing as they reach the limit of their potential. The OMG study3 showed that this rate and limit vary considerably among children with CP, even within GMFCS level. The Stable Limit model has two parameters, corresponding to the rate and limit of motor change as a function of age.
The results of the Stable Limit model are contrasted with a ‘Peak and Decline’ model. Within the age range 2 to 21 years, the Peak and Decline model will make predictions very similar to the Stable Limit model if there is no evidence of decline in GMFM-66 scores. However, the Peak and Decline model has one extra parameter, and this allows for predictions that may show a peak and decline in score, before a long-term limit. Mathematical details of the two models are given in Appendix SI (Supporting Information published online).
To account for the longitudinal structure of the data, both models were estimated as nonlinear mixed-effects models.16,17 The mixed-effects framework allows for the estimation of the average pattern of change within GMFCS level. In addition, orderly variations in the pattern of development between children are accommodated by allowing for individual variation in the parameters that characterize the change function. In effect, individual motor development curves are fitted for each child. The nonlinear mixed-effects models were estimated by maximum likelihood using the NLME software routines implemented in the S-Plus statistical programming language.18
To evaluate whether a peak and decline in GMFM-66 occurs, we compared the overall fit of the models using the Akaike Information Criterion (AIC) statistic, which is a standard measure of model fit.19 Models with lower AIC fit better to the data. AIC incorporates a penalty for models having more parameters, so if there is no peak and decline evident in the data, the simpler Stable Limit model will be preferred to the Peak and Decline model.
For GMFCS levels where a peak and decline is discovered, we used the estimated parameters of the Peak and Decline model to estimate the average age at peak GMFM-66, and we calculated the average size of the decline from peak GMFM-66 to the estimated long-term limit of GMFM-66. Further detail is given in Appendix SI.
Table I shows mean GMFM-66 by GMFCS and age. Although this simple summary uses crude age bands, and does not account for the multiple observations per child, it suggests that the nonlinear trend in GMFM-66 over age may differ by GMFCS level. The trend in means shows no evidence of peak and decline for Levels I and II, whereas there is a suggestion of such a decline for levels IV and V. The trend for level III is not clear.
|Level I (na=183)||Mean||72.5||84.0||86.9||87.1||87.6|
|95% CI||71.1, 73.9||82.8, 85.2||85.5, 88.4||85.5, 88.7||85.9, 89.3|
|Level II (na=80)||Mean||55.7||60.1||71.0||70.6||70.8|
|95% CI||54.3, 57.1||63.2, 66.9||69.1, 72.8||68.7, 72.4||69.1, 72.5|
|Level III (na=122)||Mean||49.7||53.0||52.8||50.8||51.7|
|95% CI||48.7, 50.8||52.0, 54.3||51.7, 54.9||49.0, 52.7||50.0, 53.4|
|Level IV (na=137)||Mean||38.8||41.4||39.2||38.6||34.4|
|95% CI||37.7, 40.0||40.2, 42.6||38.0, 40.5||36.1, 40.3||32.7, 36.2|
|Level V (na=135)||Mean||23.1||24.8||21.0||21.9||22.7|
|95% CI||21.9, 24.2||23.5, 26.0||19.3, 22.6||20.1, 23.7||19.8, 25.6|
The results of fitting the nonlinear mixed-effects Stable Limit and Peak and Decline models are given in Table II. The two parameters for the Stable Limit models are estimates of the rates and limits of motor change. Consistent with our previous research,3 the clinical interpretability of the rate parameter has been improved by transforming it to Age90. This is easily interpreted as the average age at which children achieve 90% of their expected limit in GMFM-66 motor ability. Thus, smaller values of Age90 (in years) indicate faster progress toward motor development limits. The Peak and Decline models are governed by three parameters, including a limit that is interpreted as in the Stable Limit models. For GMFCS Levels I and II, the Stable Limit and Peak and Decline models produce similar limit estimates, whereas the Peak and Decline limits are lower than those for the Stable Limit model for Levels III to V. The other parameters in the Peak and Decline model are the predicted GMFM-66 at 6 years of age, and a rate parameter. The Peak and Decline rate parameter cannot be transformed to a clinically meaningful quantity, such as Age90, so its interpretability is limited. Instead, we use all the Peak and Decline model parameters to calculate the predicted age at which peak GMFM-66 score is achieved for the average child.
|I (n=183)||II (n=80)||III (n=122)||IV (n=137)||V (n=135)|
|Mean number of observations per child||5.3||5.8||5.2||5.1||4.7|
|AIC model fit||SL model||6091a||2719a||4026||4165||3984|
|SL model||GMFM-66 limit||89.5||68.5||53.5||39.5||22.1|
|(95% CI)||(87.7, 91.0)||(66.0, 71.0)||(51.9, 55.0)||(38.2, 40.9)||(20.6, 23.6)|
|Age90||5y 2mo||4y 11mo||3y 2mo||3y 2mo||2y 5mo|
|(95% CI)||(4y 10mo, 5y 8mo)||(4y 4mo, 5y 6mo)||(2y 8mo, 3y)||(2y 8mo, 3y 1mo)||(1y 6mo, 3y 8mo)|
|PD model||GMFM-66 limit||87.1||67.2||47.4||33.5||17.3|
|(95% CI)||(85.4, 88.9)||(64.9, 69.3)||(44.2, 50.6)||(30.7, 36.3)||(14.0, 20.6)|
|Predicted GMFM-66 at age 6y||78.7||60.8||51.2||41.1||23.6|
|(95% CI)||(77.1, 80.3)||(58.4, 63.2)||(49.9, 52.5)||(39.7, 42.5)||(21.9, 25.2)|
|(95% CI)||(0.952, 0.966)||(0.937, 0.961)||(0.974, 0.980)||(0.977, 0.981)||(0.978, 0.984)|
Based on comparisons of AICs, the Stable Limit model fits better for GMFCS Levels I and II, whereas the Peak and Decline model fits better for Levels III to V. This suggests that the average patterns of GMFM-66 include peaks and declines before arriving at the limits of gross motor ability for Levels III to V, but not Levels I and II. Examination of the residual standard deviations (SDs) for each group supports the model choices based on AIC. The SDs indicate the average degree of within-child deviations of observed GMFM-66 scores from children’s individualized trajectories predicted by the Stable Limit and Peak and Decline models. The SDs for the Stable Limit and Peak and Decline models are comparable for GMFCS Levels I and II, reflecting the similarity of predictions when no peak and decline is present. However, the residual SDs in Table II are considerably smaller for the Peak and Decline than Stable Limit models for GMFCS III to V, reflecting the predictive advantage for a model that can accommodate peak and decline in GMFM-66. Inspection of the standardized residuals for the best fitting model in each level suggested that they conform to the assumptions of the nonlinear mixed-effects model.
The predicted average GMFM-66 trajectories from the best models in each GMFCS level are illustrated in Figure 1. The dashed lines illustrate the timing of the peak and highlight the loss from the peak to age 21 years. Table III provides the estimated parameters of the best fitting models, the estimated average age of the peak GMFM-66, and average decline from peak to limit, for GMFCS Levels III to V. The estimated peaks occur well before adolescence (7y 11mo, 6y 11mo, and 6y 11mo respectively). The predicted declines in GMFM-66 range from 4.7 points in GMFCS Level III to 7.8 points in Level IV.
|Stable Limit models||Peak/Decline models|
|Average GMFM-66 limit||89.5||68.5||47.4||33.5||17.3|
|50% range||81.0, 94.4||61.0, 75.2||38.7, 56.1||26.1, 41.0||9.7, 25.0|
|Average Age90||5y 2mo||4y 11mo|
|50% range||4y 1mo, 6y 8mo||3y 7mo, 6y 6mo|
|Average predicted GMFM-66 at age 6y||51.2||41.1||23.6|
|50% range||47.1, 55.2||36.2, 46.0||17.6, 29.6|
|Peak/Decline||Age at peak (y)||7y 11mo||6y 11mo||6y 11mo|
|(95% CI)||(6y 10mo, 9y)||(6y 2mo, 7y 6mo)||(5y 10mo, 7y 11mo)|
|50% range||3y 8mo, 12y 1mo||4y 6mo, 9y 2mo||3y 6mo, 10y 4mo|
|GMFM-66 loss from peak to limit||4.7||7.8||6.4|
|(95% CI)||(1.9, 7.5)||(4.9, 10.6)||(2.8, 10.0)|
|50% rangeb||0, 13.1||0, 16.9||0, 16.6|
To illustrate the clinical consequences of these declines, Table IV relates scores at the average peak and decline to expected performance on selected GMFM items. The probabilities of completing these items (i.e. scoring the maximum, 3) were computed from established Rasch model results for the GMFM-66.10Table IV shows that the estimated declines can have a clinically meaningful effect on the probability of performing items that are most diagnostic of motor ability in each level. These are items with moderate probabilities at peak function, which are highlighted in Table IV. For example, with an average peak score of 52.2, children in GMFCS Level III have moderate probabilities of successfully completing the standing and supported walking items 35, 68, and 53. The relatively small predicted loss of 4.7 points from peak to limit dramatically decreases the probability of success for these items. The larger predicted loss of 7.8 points for children in GMFCS Level IV all but eliminates the moderate probabilities of attaining the sitting and four-point mobility items 34, 41, and 44.
|Item||Level III||Level IV||Level V|
|Peak (52.2)||Limit (47.5)||Peak (41.3)||Limit (33.5)||Peak (23.7)||Limit (17.3)|
|10. Prone, lifts head||99.5||98.8||96.6||88.0||52.5||17.9|
|23. Sitting, arms propping, 5s||99.6||99.1||97.3||89.5||37.8||4.0|
|22. Supported at thorax, lifts head to midline, 10s||99.3||98.5||95.6||84.0||38.4||9.1|
|34. Sits on bench, 10s||93.6||85.7||59.3||10.0||<1||<1|
|41. Prone, attains four-point||94.6||85.7||48.2||3.6||<1||<1|
|44. Four-point crawl or hitch, 10f (3.048 m)||97.0||87.0||31.2||1.0||<1||<1|
|35. From standing, sits on bench||74.8||35.3||3.3||<1||<1||<1|
|68. Walks 10 steps, one hand held||57.7||19.0||1.4||<1||<1||<1|
|53. Stand arms-free, 3s||40.1||16.1||2.3||<1||<1||<1|
|69. Walks 10 steps, no support||14.6||1.6||<1||<1||<1||<1|
Of course, not all children will experience the average pattern of change for their level. The nonlinear mixed-effects model estimates individual differences in all parameters of change as variance components. These are reported in Table III for each of the parameters, as well as for the resulting peak and decline estimates, transformed to ‘50% ranges’ for ease of interpretation. The 50% ranges give the values of the parameter expected for the middle 50% of children. Note that they are not confidence intervals: rather, they give an indication of the expected variability in the change pattern among children. Although the average patterns of change in Levels III to V show a decline in GMFM-66, the 50% ranges indicate that the degree of this decline varies considerably among children.
Williams20 observed that ‘children with disability grow into adults with a disability’, and has called for more attention to adolescence as a key time of transition and an understudied area of disability research and service. This is particularly relevant for youth with CP because therapeutic and support services are also in transition during this period; care often shifts from children’s treatment centers, school support, and early childhood education programs to less intensive and less available adult primary care and rehabilitation.
The present study complements and sharpens the suggestive findings of Day et al.7 Previous work has focused on ambulation, and thus on the higher-functioning children and youth. By contrast, our study presents a detailed and comprehensive account of changes in adolescent gross motor function across the entire spectrum of CP. Previous research suggested that the likelihood of loss might be related to initial overall activity limitation, but none used a validated and reliable classification of activity limitations.7 By using the five levels of the GMFCS, it is possible to show in detail where functional peak and loss are likely to happen and when in development they occur. This information is now specific enough to be of practical use to clinicians, children, and families.
The findings indicate that children and youth in Levels III, IV, and V are at risk of losing motor function, with the greatest declines apparent in Level IV. Although the specific explanation for these findings requires further prospective study, we can speculate that some combination of physical growth and decreased self-initiated motor function (perhaps related to the effort involved) may be associated with a ‘natural’ tendency toward increased energy costs, contractures, and muscle stiffness that have been somewhat held at bay in the earlier years. Changes in spinal alignment may also be relevant. We are currently exploring this question using additional clinical data collected systematically in the ASQME study.
Consistent with these ideas, Bottos and Gericke21 and Pimm22 suggest that, among adolescents and young adults, the transition to adult body size and the increasing imbalance between physiological resources and changing environmental demands over time may mean that the maintenance of previously achieved motor function becomes prohibitively demanding for some persons. Jahnsen et al.23 found that fatigue was higher among adults with CP than in the general population. Murphy et al.24 found that joint deterioration or pain was a common reason for adults to stop walking independently later in life, but not before age 25.
Because we did not rely on self-reports of usual mobility, it is possible to distinguish what children can do (capacity) from what they choose to do (performance). Our use of a standardized measure suggests it is more likely that the peak/loss observed here is related to children’s capacity, rather than their preferences. We exploited the Rasch scaling of the GMFM-66 to show that the average losses of 4.7 to 7.8 points are large enough to produce clinically meaningful changes in the performance of some important gross motor tasks (see Table IV). The implications for usual mobility in diverse settings remain to be seen.
Our longitudinal study design allows us to comment on between-child variations in the changes in function. This is important because of the large variability within levels. Clinicians and families should not assume that the average pattern applies to all children in a GMFCS level. The substantial variation in the degree of loss estimated from these data emphasizes that children in Levels III to V are not ‘destined’ to lose function in adolescence. Rather, we estimate the risk of loss and its variations. The challenges now are to predict more accurately who will experience peak/loss within levels and how it can be mitigated. For example, Damiano4 and others have suggested that exercise, physical activity, and participation are crucial to maintaining function as persons with CP age. Obesity may also be an important factor, and we are conducting further work to investigate this.
We believe that our observations about peak and loss of gross motor function will be useful for service providers and families, and for researchers seeking to describe the life course of young people with CP.
- 1A report: the definition and classification of cerebral palsy April 2006. Dev Med Child Neurol 2007; 49 (Suppl. 109): 8–14. Erratum in: Dev Med Child Neurol 2007; 49: 480., , , et al.
- 10Gross Motor Function Measure (GMFM-66 and GMFM-88) user’s manual. Clinics in Developmental Medicine, No. 159. London: Mac Keith Press, 2002., , , .
- 16Mixed-effects models for S and S-Plus. New York: Springer, 2000., .
- 17Nonlinear models for repeated measurement data. London: Chapman and Hall, 1995., .
- 18S-Plus. Enterprise Developer Version 7.0.6 for Microsoft Windows. Seattle, WA: Insightful Corporation, 2005.
- 19Model selection and multi-model inference: a practical information-theoretic approach. 2nd edn. New York: Springer, 2002., .
- 22Cerebral palsy: a non progressive disorder? Educat Child Psychol 1992; 9: 27–33..
Appendix SI: Statistical Appendix (The Stable Limit Model and the Peak/Decline Model)
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|DMCN_3196_sm_appendix.pdf||20K||Supporting info item|
Please note: Wiley-Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.