Corrections added after online publication 20 August 2009: The positions of the last two authors’ names have been exchanged.
Cognitive outcome following unilateral arterial ischaemic stroke in childhood: effects of age at stroke and lesion location
Article first published online: 20 AUG 2009
© The Authors. Journal compilation © Mac Keith Press 2009
Developmental Medicine & Child Neurology
Volume 52, Issue 4, pages 386–393, April 2010
How to Cite
WESTMACOTT, R., ASKALAN, R., MACGREGOR, D., ANDERSON, P. and DEVEBER, G. (2010), Cognitive outcome following unilateral arterial ischaemic stroke in childhood: effects of age at stroke and lesion location. Developmental Medicine & Child Neurology, 52: 386–393. doi: 10.1111/j.1469-8749.2009.03403.x
- Issue published online: 4 MAR 2010
- Article first published online: 20 AUG 2009
- PUBLICATION DATA Accepted for publication 22nd May 2009. Published online 20 August 2009.
Aim Plasticity in the developing brain is a controversial issue. Although language and motor function often recover remarkably well following early brain injury, recent evidence suggests that damage to the developing brain results in significant long-term neuropsychological impairment. Our aim was to investigate the relationship among age at injury, lesion location and intellectual outcome.
Method Using age-appropriate Wechsler scales of intellectual ability, we explored this issue by evaluating a large group (n=145) of children (89 males, 56 females) who experienced unilateral arterial ischaemic stroke during the perinatal period (diagnosed mean 73d, SD 29d), between the ages of 1 month and 5 years (mean 2y 10mo, SD 1y 9mo), or between the ages of 6 and 16 years (mean 11y 1mo SD 3y 6mo). The mean age at assessment was 8 years (SD 3y 10mo) in the perinatal group, 7 years 5 months (SD 2y 9mo) in the 1 month to 5 years group, and 12 years 5 months (SD 3y 9mo) in the 6 to 16 years group. The mean time interval between stroke and assessment was 8 years (SD 18d) for perinatal, 4 years 6 months (SD 1y 5mo) for 1 month to 5 years, and 1 year 4 months (SD 2y 9mo) for 6 to 16 years. The relationship between age at stroke and lesion location (subcortical, cortical, or combined) as it pertains to cognitive outcome was also examined.
Results Measures of overall intelligence, verbal ability, working memory, and processing speed were significantly lower in children who had had a stroke than in the normative sample (all z>2.5, all p<0.01). The perinatal group performed more poorly than the other two groups on most cognitive measures, regardless of lesion location. The combined lesion location group performed more poorly than those with damage to either cortical or subcortical areas alone. Further investigation revealed different periods of peak vulnerability for subcortical lesions (perinatal) and cortical lesions (1mo–5y).
Interpretation Lesion location modulates the relationship between age at stroke and cognitive outcome.