Hand function in relation to brain lesions and corticomotor-projection pattern in children with unilateral cerebral palsy

Authors


  • Acknowledgments
    We wish to express our deepest gratitude to the children and families who participated in this study. We also thank Dr Olof Flodmark, Professor at the Department of Neuroradiology, Karolinska University Hospital for participating in scoring of the magnetic resonance images. This study was supported by the Health Care Sciences Postgraduate School at Karolinska Institutet, Swedish Research Council, Stockholm County Council, FoU Committee, and Stiftelsen Frimurare Barnhuset. Dr Brigitte Vollmer was funded by a Marie Curie Intra-European Fellowship within the EU FP6 Framework Programme.

Linda Holmström at the Neuropediatric Research Unit, Q2:07, Astrid Lindgren Children’s Hospital, 171 76 Stockholm, Sweden. E-mail: linda.holmstrom@ki.se

Abstract

Aim  To investigate relationships between hand function, brain lesions, and corticomotor projections in children with unilateral cerebral palsy (CP).

Method  The study included 17 children (nine males, eight females; mean age 11.4 [SD 2.4] range 7–16y), with unilateral CP at Gross Motor Function Classification System level I and Manual Ability Classification System level I or II. Hand function was assessed with the Box and Blocks test and Assisting Hand Assessment (AHA). Conventional structural magnetic resonance images were assessed visually for type, location, and extent of brain lesions. Single-pulse transcranial magnetic stimulation (TMS) provided information on organization of corticomotor projections.

Results  The most favourable hand function was seen in children who had white-matter damage of immaturity with mild white-matter loss and contralateral motor projections. Children with ipsilateral projections had the most impaired function. Nevertheless, in this subgroup a range of ability was seen (AHA 29–59%). Motor-projection patterns appeared to be influenced by lesion extent and location, but not by lesion type.

Interpretation  Combining information from structural magnetic resonance images and TMS can improve prediction of hand function. A wide variation in hand function was seen within all motor-projection patterns. Although the most impaired hand function was seen in the ipsilateral motor-projection group, some children in this group had fairly good ability. Such information is important for treatment planning.

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