The association of genetic polymorphisms with cerebral palsy: a meta-analysis


Professor Jiu-Lai Tang at Department of Paediatrics, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei 230022, China. E-mail:


Aim  The aim of our meta-analysis was to summarize quantitatively the association of genetic polymorphisms with cerebral palsy (CP).

Method  We identified 16 studies on the association of genetic polymorphisms with CP in Pubmed, Elsevier Science Direct, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure, and Wanfang. Eleven of these studies (involving a total of 2533 cases and 4432 controls) were used in the current meta-analysis. A study was included if (1) it was published up to September 2010 and (2) it was a case–control study. We excluded one study of family members because the analysis was based on linkage considerations. Meta odds ratios and 95% confidence intervals based on fixed-effects models or random-effects models were dependent on Cochran’s Q statistic. We examined the relationship between alleles, as well as genotypes and susceptibility to CP.

Results  Meta-analysis was performed for 17 genetic polymorphisms: apolipoprotein E (ε2,ε3,ε4), methylenetetrahydrofolate reductase (MTHFR) (rs1801133), coagulation factor II (rs1799963]), coagulation factor V (rs6025), coagulation factor VII (rs5742910/rs6046), interleukin-6 (IL-6) (rs1800795), endothelial nitric oxide (rs1800779/rs1799983/rs3918226), fibrinogen β-polypeptide (rs1800790), plasminogen activator inhibitor 1 (rs1799768/rs7242), TNF-β lymphotoxin α precursor (rs1041981), adducin 1 (α) (rs4961), ADRB2 (rs1042714), and tumour necrosis factor α (rs1800629). We found a significant association between CP and IL-6 (rs1800795) [C vs G: odds ratio (OR) 1.79, 95% confidence interval (CI) 1.44–2.22, p<0.001; CC+GC vs GG: OR 1.72, 95% CI 1.29–2.29, p=0.002; CC vs GG+GC: OR 2.17, 95% CI 1.52–3.09, p<0.001], but no other genetic polymorphisms.

Interpretation  This meta-analysis demonstrated that CP is associated with the genetic polymorphism IL-6 (rs1800795).