This article is commented on by Santosh on pages 206207 of this issue.
Imaging evidence for disturbances in multiple learning and memory systems in persons with autism spectrum disorders
Article first published online: 23 JAN 2012
© The Authors. Developmental Medicine & Child Neurology © 2012 Mac Keith Press
Developmental Medicine & Child Neurology
Volume 54, Issue 3, pages 208–213, March 2012
How to Cite
GOH, S. and PETERSON, B. S. (2012), Imaging evidence for disturbances in multiple learning and memory systems in persons with autism spectrum disorders. Developmental Medicine & Child Neurology, 54: 208–213. doi: 10.1111/j.1469-8749.2011.04153.x
- Issue published online: 10 FEB 2012
- Article first published online: 23 JAN 2012
- PUBLICATION DATA Accepted for publication 21st August 2011. Published online 23rd January 2012.
Aim The aim of this article is to review neuroimaging studies of autism spectrum disorders (ASD) that examine declarative, socio-emotional, and procedural learning and memory systems.
Method We conducted a search of PubMed from 1996 to 2010 using the terms ‘autism,’‘learning,’‘memory,’ and ‘neuroimaging.’ We limited our review to studies correlating learning and memory function with neuroimaging features of the brain.
Results The early literature supports the following preliminary hypotheses: (1) abnormalities of hippocampal subregions may contribute to autistic deficits in episodic and relational memory; (2) disturbances to an amygdala-based network (which may include the fusiform gyrus, superior temporal cortex, and mirror neuron system) may contribute to autistic deficits in socio-emotional learning and memory; and (3) abnormalities of the striatum may contribute to developmental dyspraxia in individuals with ASD.
Interpretation Characterizing the disturbances to learning and memory systems in ASD can inform our understanding of the neural bases of autistic behaviors and the phenotypic heterogeneity of ASD.