Coeliac disease, epilepsy, and cerebral calcifications: association with TG6 autoantibodies
Article first published online: 31 JUL 2012
© 2012 The Authors. Developmental Medicine & Child Neurology © 2012 Mac Keith Press
Developmental Medicine & Child Neurology
Volume 55, Issue 1, pages 90–93, January 2013
How to Cite
JOHNSON, A. M., DALE, R. C., WIENHOLT, L., HADJIVASSILIOU, M., AESCHLIMANN, D. and LAWSON, J. A. (2013), Coeliac disease, epilepsy, and cerebral calcifications: association with TG6 autoantibodies. Developmental Medicine & Child Neurology, 55: 90–93. doi: 10.1111/j.1469-8749.2012.04369.x
- Issue published online: 13 DEC 2012
- Article first published online: 31 JUL 2012
- Accepted for publication 2nd May 2012. , Published online.
A 4-year-old boy presented with occipital seizures but normal initial neuroimaging and proved refractory to antiepileptic medications. On repeat neuroimaging after 1 year, he had developed bi-occipital calcification and was then found to have positive coeliac serology. He was diagnosed with coeliac disease, epilepsy, and cerebral calcifications (CEC) and became seizure free after starting the gluten-free diet. Positive antibody binding to neurons and glia was demonstrated on indirect immunofluorescence. High levels of immunoglobulin-A directed against transglutaminase isoenzyme 6 (TG6) were found in the patient’s serum. The positive response to the diet, TG6 antibodies, and neuronal antibody binding suggest that CEC might be autoimmune in nature, as in other extra-intestinal manifestations of gluten-related diseases, such as gluten ataxia.