This research was supported by NIMH Grants MH32103 and MH38118 to Rafacl Klorman. Joan Brumaghm's particiation was funded in part by a postdoctoral research fellowship from NIMH Grant MH1708. We are grateful for the help of Keith Conners. David Kurtz. Jan Loney James Metz. Lawrence Ota. William Pelham, Helen Pollock. Harry Rers. David Williams, and the Strong Memorial Hospital Pharmacy.
Effects of Methylphenidate on Processing Negativities in Patients With Attention-deficit Hyperactivity Disorder
Article first published online: 30 JAN 2007
Volume 27, Issue 3, pages 328–337, May 1990
How to Cite
Klorman, R., Brumaghim, J. T., Salzman, L. F., Strauss, J., Borgstedt, A. D., McBride, M. C. and Loeb, S. (1990), Effects of Methylphenidate on Processing Negativities in Patients With Attention-deficit Hyperactivity Disorder. Psychophysiology, 27: 328–337. doi: 10.1111/j.1469-8986.1990.tb00391.x
- Issue published online: 30 JAN 2007
- Article first published online: 30 JAN 2007
- (Manuscript received May 18, 1988; accepted for publication June 25, 1989)
- Processing negativity;
- Attention deficit-Hyperactivity Disorder;
This study compared the impact of methylphenidate on patients with Attention-deficit Hyperactivity Disorder (ADHD) with and without aggressive/noncompliant features in an oddball test consisting of a randomly ordered series of loud (frequent) tones, soft (rare) tones, bright (frequent) lights, and dim (rare) lights. In alternate conditions, subjects were required to respond to either the rare tones or the rare lights. These tasks were administered in a drug-free baseline session and after a counterbalanced treatment of 14 days each of methylphenidate (0.3 mg/Kg b.i.d.) and placebo (lactose b.i.d.). In comparison with placebo, methylphenidate resulted in greater accuracy and speed of reactions to targets of both modalities. The amplitude of N1 to auditory nontargets was larger when the target was a rare tone as opposed to a rare light, and this attention-related effect was increased by methylphenidate. The same differential amplitude enhancement by stimulant treatment was found for an early area measure of difference ERPs. In contrast, for N1 to visual nontargets the effect of selective attention (larger amplitude when the target was a rare light vs. a rare tone) was not significant and was not affected by stimulant medication. All these findings were comparable for the three ADHD subgroups, a result attesting to the generality of stimulant effects on information processing.