This work was supported by grants from the U.S. Public Health Service (National Institute of Mental Health MH44643 and Institutional National Research Scientist Award AG00143), the Medical Research Council of Canada, and the Canada Health and Welfare National Research Directorate Program. Scott Sponheim was supported by a training grant from the National Institute of Mental Health (MH17069).
Resting EEG in first-episode schizophrenia patients, bipolar psychosis patients, and their first-degree relatives
Version of Record online: 30 JAN 2007
Volume 31, Issue 5, pages 486–494, September 1994
How to Cite
CLEMENTZ, B. A., SPONHEIM, S. R., IACONO, W. G. and BEISER, M. (1994), Resting EEG in first-episode schizophrenia patients, bipolar psychosis patients, and their first-degree relatives. Psychophysiology, 31: 486–494. doi: 10.1111/j.1469-8986.1994.tb01052.x
- Issue online: 30 JAN 2007
- Version of Record online: 30 JAN 2007
- (Received April 28, 1993; Accepted November 19, 1993)
- Bipolar disorder;
- First-episode psychosis;
- Family study
We evaluated the resting electroencephalogram (EEG) of 50 first-episode schizophrenia patients and 55 of their relatives, 31 first-episode bipolar patients and 35 of their relatives, and 113 nonpsychiatric subjects and 42 of their relatives. The frequency characteristics of the EEG showed moderate stability for a subgroup of these subjects (n= 106) who were tested twice, approximately 9 months apart. Both the schizophrenia and bipolar patients showed a generalized pattern of increased delta and theta and decreased alpha activity. The bipolar patients demonstrated additional right hemisphere activity that was not present among the schizophrenia patients and nonpsychiatric subjects, a finding consistent with hypotheses concerning nondominant hemisphere involvement in the regulation of elated mood. The schizophrenia patients' female relatives and/or relatives with affective disorders and the bipolar patients had significantly reduced peak alpha frequencies. This finding may be related to reduced information processing capacity among these subjects.