This study was supported by grant nos. HL44915, HL36005, RR00827, and HL35924 and by Clinical Research Center grant no. M01RR00827 from the National Institutes of Health.
Assessment of baroreflex control from beat-to-beat blood pressure and heart rate changes: A validation study
Version of Record online: 30 JAN 2007
Volume 32, Issue 4, pages 411–414, July 1995
How to Cite
WATKINS, L. L., FAINMAN, C., DIMSDALE, J. and ZIEGLER, M. G. (1995), Assessment of baroreflex control from beat-to-beat blood pressure and heart rate changes: A validation study. Psychophysiology, 32: 411–414. doi: 10.1111/j.1469-8986.1995.tb01224.x
- Issue online: 30 JAN 2007
- Version of Record online: 30 JAN 2007
- (Received January 7, 1994; Accepted August 12, 1994)
- Baroreflex control;
In this study, we tested the validity of a new method designed to estimate baroreflex control of heart rate from spontaneous changes in systolic pressure and pulse interval. This method was compared with a conventional method of assessing baroreflex control through measuring reflex adjustments in pulse interval associated with pharmacological manipulations of blood pressure. The estimates of baroreflex control derived from the two methods were signficantly correlated; however, only the estimate derived using pharmacological changes in pressure detected significant impairment of baroreflex control in patients with damage to baroafferents produced by radiation for oropharyngeal cancer. Analysis of spontaneous changes in pressure and pulse interval therefore provide a meaningful estimate of baroreflex control of heart rate that is, however, less sensitive than estimates obtained using pharmacological manipulations in pressure.