This research was supported by the Deutsche Forschungsgemeinschaft (German Research Council).
Enhanced psychophysiological signs of attention after angiotensin-converting enzyme inhibition by captopril
Version of Record online: 30 JAN 2007
Volume 33, Issue 3, pages 295–301, May 1996
How to Cite
DERAD, I., PIETROWSKY, R., DODT, C., FEHM, H. L. and BORN, J. (1996), Enhanced psychophysiological signs of attention after angiotensin-converting enzyme inhibition by captopril. Psychophysiology, 33: 295–301. doi: 10.1111/j.1469-8986.1996.tb00426.x
We thank Prof. Dr. P. Dominiak for helpful advice and A. Otterbein, C. Zinke, and S. Baxmann for technical assistance.
- Issue online: 30 JAN 2007
- Version of Record online: 30 JAN 2007
- (Received August 18, 1994; Accepted March 31, 1995)
- Angiotensin-converting enzyme inhibitor;
- Cardiovascular activity;
- Auditory event-related potentials;
Complementary to its essential role in the central nervous control of cardiovascular activity, the neuropeptide angiotensin 11 may regulate attentional processes. The present study evaluated central nervous, cardiovascular, and sympathetic indicators of attention after inhibition of angiotensin II synthesis by captopril (50 mg vs. placebo) in 14 men. Event-related potentials (ERPs) and stimulus-related electroencephalographic (EEG) activity were recorded while the subject performed an auditory oddball task. Captopril increased both the N1-P2 component of the ERP (p < .05) and – following the first tone of the task – the EEG desynchronization in the lower alpha frequency band (p < .05). Although blood pressure remained unchanged, heart rate was lowered (p < .05) and plasma norepinephrine concentrations increased (p < .01) after captpril. The effects suggest that inhibition of angiotensin II synthesis enhances an attentional state typically present during sensory intake.