This research was supported by grants from the Mental Illness and Neuroscience Discovery (MIND) Institute and NIMH (R01 MH65304) to Jose M. Cañive and from the National Alliance for Research on Schizophrenia and Depression (NARSAD) to Robert J. Thoma. The authors thank Robin Douglas, Fernando Torres, Kimberly Martin, Lawrence Calais, Jeanne Schneider, and Juan Bustillo for their recruitment efforts and Lawrence Hubert and Steven Gangestad for statistical consultation.
Distinct M50 and M100 auditory gating deficits in schizophrenia
Article first published online: 22 JUN 2005
Volume 42, Issue 4, pages 417–427, July 2005
How to Cite
Hanlon, F. M., Miller, G. A., Thoma, R. J., Irwin, J., Jones, A., Moses, S. N., Huang, M., Weisend, M. P., Paulson, K. M., Edgar, J. C., Adler, L. E. and Cañive, J. M. (2005), Distinct M50 and M100 auditory gating deficits in schizophrenia. Psychophysiology, 42: 417–427. doi: 10.1111/j.1469-8986.2005.00299.x
- Issue published online: 22 JUN 2005
- Article first published online: 22 JUN 2005
- (Received August 31, 2004; Accepted February 11, 2005)
- Auditory sensory gating;
The time course of the schizophrenia auditory gating deficit may provide clues to mechanisms of impaired cognition. Magnetoencephalography was recorded during a standard paired-click paradigm. Using source strength of the M50 and M100 components for each click, calculated from dipole locations identified as underlying each component for the first click, a ratio of the second divided by the first was used to measure gating. Patients showed a left-hemisphere gating deficit in M50 and a bilateral gating deficit in M100. Hypothesizing that an early deficit may affect later processing, hierarchical regression was used to examine variance shared between the components. A left-hemisphere M100 gating deficit was coupled with the left M50 gating deficit. In contrast, a right-hemisphere M100 gating deficit was unrelated to M50 gating in either hemisphere. Investigations of interhemisphere gating relations may clarify group differences in regional connectivity and their role in gating.