This research was supported in part by United States Public Health Service Grants AA09367, DA05147, and MH65137.
Genes mediate the association between P3 amplitude and externalizing disorders
Article first published online: 15 NOV 2006
Volume 44, Issue 1, pages 98–105, January 2007
How to Cite
Hicks, B. M., Bernat, E., Malone, S. M., Iacono, W. G., Patrick, C. J., Krueger, R. F. and McGue, M. (2007), Genes mediate the association between P3 amplitude and externalizing disorders. Psychophysiology, 44: 98–105. doi: 10.1111/j.1469-8986.2006.00471.x
- Issue published online: 15 NOV 2006
- Article first published online: 15 NOV 2006
- (Received December 30, 2005; Accepted June 21, 2006)
- P3 amplitude;
- Externalizing disorders;
- Substance abuse;
- Antisocial behavior;
Reduced P3 amplitude has been consistently linked to a spectrum of externalizing disorders. Utilizing data from a large sample of adolescent male twins (N=1196), we used biometric modeling to assess the genetic and environmental contributions to the association between reduced P3 amplitude and a general vulnerability to externalizing disorders. Externalizing vulnerability was indexed by a composite of symptoms of conduct disorder, adult antisocial behavior, and alcohol, nicotine, and drug dependence. The sample included two independent age cohorts, providing an internal replication of the findings. For the best-fitting model, genetic influences alone accounted for the association between P3 amplitude and externalizing disorders, with an estimated genetic correlation of rg=−.22. Results replicated across the two age cohorts and demonstrate that reduced P3 amplitude is a marker of the biological vulnerability to externalizing disorders.