This study was supported by the German Research Foundation (Project-No.: SCHA 308/17-3). We are very grateful to Prof. Dr. Jens Jordan for providing us with pharmacological information. Katrin Holler was a great help with subject acquisition and organization of the study.
Enhancement of cerebral blood flow and cognitive performance following pharmacological blood pressure elevation in chronic hypotension
Article first published online: 15 NOV 2006
Volume 44, Issue 1, pages 145–153, January 2007
How to Cite
Duschek, S., Hadjamu, M. and Schandry, R. (2007), Enhancement of cerebral blood flow and cognitive performance following pharmacological blood pressure elevation in chronic hypotension. Psychophysiology, 44: 145–153. doi: 10.1111/j.1469-8986.2006.00472.x
- Issue published online: 15 NOV 2006
- Article first published online: 15 NOV 2006
- (Received April 26, 2006; Accepted September 12, 2006)
- Blood pressure;
- Cerebral blood flow;
- Doppler sonography
Previous research has demonstrated reduced cognitive performance and diminished cerebral blood flow in the case of chronic hypotension. We investigated whether these deficits can be reduced by pharmacological blood pressure elevation. Effects of the sympathomimetic midodrine were examined in 50 hypotensive individuals based on a randomized, placebo-controlled double-blind design. A paper–pencil test assessing performance in selective attention was presented. By means of transcranial Doppler sonography, blood flow velocities were recorded in both middle cerebral arteries at rest and during the execution of a cued reaction time task. The administration of midodrine led to an increase in blood flow velocities at rest as well as enhanced attentional performance. The degree of rise in flow velocities was positively correlated with performance enhancement. The increase in flow velocities observed during the execution of the reaction time task was stronger following drug administration.