This research was supported by the National Institute of Drug Abuse (R21 DA14111), the National Institute of Mental Health (R01 MH61358, T32 MH14257, T32 MH19554), and the University of Illinois Beckman Institute and Intercampus Research Initiative in Biotechnology. Anna S. Engels was a predoctoral trainee in the Cognitive Psychophysiology training program of the Department of Psychology, University of Illinois at Urbana–Champaign, under NIMH Grant T32 MH19554. John D. Herrington was a predoctoral trainee in the Quantitative Methods training program of the Department of Psychology, University of Illinois at Urbana–Champaign, under NIMH Grant T32 MH14257.
Differential engagement of anterior cingulate cortex subdivisions for cognitive and emotional function
Article first published online: 8 APR 2007
Volume 44, Issue 3, pages 343–351, May 2007
How to Cite
Mohanty, A., Engels, A. S., Herrington, J. D., Heller, W., Ringo Ho, M.-H., Banich, M. T., Webb, A. G., Warren, S. L. and Miller, G. A. (2007), Differential engagement of anterior cingulate cortex subdivisions for cognitive and emotional function. Psychophysiology, 44: 343–351. doi: 10.1111/j.1469-8986.2007.00515.x
The authors thank Emily Cahill, Nancy Dodge, Rebecca Levin, Sarah Sass, Brad Sutton, Holly Tracy, and Tracey Wszalek for their contributions to this project.
- Issue published online: 8 APR 2007
- Article first published online: 8 APR 2007
- (Received September 30, 2006; Accepted November 24, 2006)
- Anterior cingulate;
- Functional connectivity;
Functional differentiation of dorsal (dACC) and rostral (rACC) anterior cingulate cortex for cognitive and emotional function has received considerable indirect support. Using fMRI, parallel tasks, and within-subject analysis, the present study directly tested the proposed specialization of ACC subdivisions. A Task × Region interaction confirmed more dACC activation during color-word distractors and more rACC activation during emotion-word distractors. Activity in ACC subdivisions differentially predicted behavioral performance. Connectivity with prefrontal and limbic regions also supported distinct dACC and rACC roles. Findings provide direct evidence for differential engagement of ACC subdivisions in cognitive and emotional processing and for differential functional connectivity in the implementation of cognitive control and emotion regulation. Results point to an anatomical and functional continuum rather than segregated operations.