Thanks, in alphabetical order, are due to Hima Bodagala, Sherine Kurian, Lorena Maili, Leslie M. Paith, Irshad N. Prasla, and Tony G. Zamudio for their help with recruitment of subjects and the General Clinical Research Center for providing research facilities and excellent nursing support. This study was supported in part by the Pat R. Rutherford, Jr., Chair in Psychiatry (A.C.S.) and by NIH grants RO1-MH 69944 (A.C.S.), RO1-DA08425 (F.G.M.), KO2-DA00403 (F.G.M.), RO1-MH58784 (N.N.B.), and UL1-RR024148 (CCTS/CRU).
P50, N100, and P200 sensory gating: Relationships with behavioral inhibition, attention, and working memory
Article first published online: 8 JUN 2009
Copyright © 2009 Society for Psychophysiological Research
Volume 46, Issue 5, pages 1059–1068, September 2009
How to Cite
Lijffijt, M., Lane, S. D., Meier, S. L., Boutros, N. N., Burroughs, S., Steinberg, J. L., Gerard Moeller, F. and Swann, A. C. (2009), P50, N100, and P200 sensory gating: Relationships with behavioral inhibition, attention, and working memory. Psychophysiology, 46: 1059–1068. doi: 10.1111/j.1469-8986.2009.00845.x
- Issue published online: 11 SEP 2009
- Article first published online: 8 JUN 2009
- (Received August 27, 2008; Accepted November 25, 2008)
- Sensory gating;
- Executive functions;
- Evoked potentials;
- Working memory;
P50, N100, and P200 auditory sensory gating could reflect mechanisms involved in protecting higher-order cognitive functions, suggesting relationships between sensory gating and cognition. This hypothesis was tested in 56 healthy adults who were administered the paired-click paradigm and two adaptations of the continuous performance test (Immediate/Delayed Memory Task, IMT/DMT). Stronger P50 gating correlated with fewer commission errors and prolonged reaction times on the DMT. Stronger N100 and P200 gating correlated with better discriminability on the DMT. Finally, prolonged P200 latency related to better discriminability on the IMT. These findings suggest that P50, N100, and P200 gating could be involved in protecting cognition by affecting response bias, behavioral inhibition, working memory, or attention.