P50, N100, and P200 sensory gating: Relationships with behavioral inhibition, attention, and working memory


  • Thanks, in alphabetical order, are due to Hima Bodagala, Sherine Kurian, Lorena Maili, Leslie M. Paith, Irshad N. Prasla, and Tony G. Zamudio for their help with recruitment of subjects and the General Clinical Research Center for providing research facilities and excellent nursing support. This study was supported in part by the Pat R. Rutherford, Jr., Chair in Psychiatry (A.C.S.) and by NIH grants RO1-MH 69944 (A.C.S.), RO1-DA08425 (F.G.M.), KO2-DA00403 (F.G.M.), RO1-MH58784 (N.N.B.), and UL1-RR024148 (CCTS/CRU).

Address reprint requests to: Marijn Lijffijt, Mental Sciences Institute, Department of Psychiatry and Behavioral Sciences, University of Texas at Houston, 1300 Moursund Avenue, Houston, TX 77030, USA. E-mail: marijn.lijffijt@uth.tmc.edu


P50, N100, and P200 auditory sensory gating could reflect mechanisms involved in protecting higher-order cognitive functions, suggesting relationships between sensory gating and cognition. This hypothesis was tested in 56 healthy adults who were administered the paired-click paradigm and two adaptations of the continuous performance test (Immediate/Delayed Memory Task, IMT/DMT). Stronger P50 gating correlated with fewer commission errors and prolonged reaction times on the DMT. Stronger N100 and P200 gating correlated with better discriminability on the DMT. Finally, prolonged P200 latency related to better discriminability on the IMT. These findings suggest that P50, N100, and P200 gating could be involved in protecting cognition by affecting response bias, behavioral inhibition, working memory, or attention.