This research was supported by the NIH grants DA 005147, DA 013240, DA 024417, and AA 009367. Special thanks to Steve Malone for helping with data processing and Matt McGue for helpful comments on an earlier draft.
The heritability of P300 amplitude in 18-year-olds is robust to adolescent alcohol use
Version of Record online: 22 JUN 2009
Copyright © 2009 Society for Psychophysiological Research
Volume 46, Issue 5, pages 962–969, September 2009
How to Cite
Perlman, G., Johnson, W. and Iacono, W. G. (2009), The heritability of P300 amplitude in 18-year-olds is robust to adolescent alcohol use. Psychophysiology, 46: 962–969. doi: 10.1111/j.1469-8986.2009.00850.x
- Issue online: 11 SEP 2009
- Version of Record online: 22 JUN 2009
- (Received September 28, 2008; Accepted December 18, 2008)
- Gene-environment interplay;
- Adolescent brain development;
- Alcohol use
P3 amplitude reduction (P3AR) is associated with adolescent alcohol use (AAU) and highly heritable, suggesting that P3AR may index a genetic predisposition (e.g., an endophenotype) for AAU. However, because P3AR and AAU covary naturally in the population, these observations are also consistent with P3AR reflecting neurotoxic effects of AAU on the developing adolescent brain. In this report, we describe the use of recent advancements in biometric modeling to examine changes in the genetic and environmental contributions to variability in P3 amplitude related to cumulative AAU by late adolescence in a large community-based twin sample. We found that the genetic and environmental contributions to variability in P3 amplitude were unaffected by AAU. This suggests that P3AR indexes risk for alcoholism independent of any deleterious effect of AAU on adolescent brain development.