This work was supported by the Academy of Finland (projects 111848, 217082, and 217113). We thank Mr. Markku Hyypiä at the Department of Psychology, University of Helsinki, for the exceptional encouragement he gave us during the preparation of the manuscript.
Mismatch negativity (MMN), the deviance-elicited auditory deflection, explained
Article first published online: 21 JUL 2009
Copyright © 2009 Society for Psychophysiological Research
Volume 47, Issue 1, pages 66–122, January 2010
How to Cite
May, P. J. C. and Tiitinen, H. (2010), Mismatch negativity (MMN), the deviance-elicited auditory deflection, explained. Psychophysiology, 47: 66–122. doi: 10.1111/j.1469-8986.2009.00856.x
- Issue published online: 17 DEC 2009
- Article first published online: 21 JUL 2009
- (Received June 5, 2008; Accepted December 23, 2008)
- Mismatch negativity (MMN);
- Event-related potential;
- Event-related field;
- Computational modeling;
- Lateral inhibition
The current review constitutes the first comprehensive look at the possibility that the mismatch negativity (MMN, the deflection of the auditory ERP/ERF elicited by stimulus change) might be generated by so-called fresh-afferent neuronal activity. This possibility has been repeatedly ruled out for the past 30 years, with the prevailing theoretical accounts relying on a memory-based explanation instead. We propose that the MMN is, in essence, a latency- and amplitude-modulated expression of the auditory N1 response, generated by fresh-afferent activity of cortical neurons that are under nonuniform levels of adaptation.