We gratefully acknowledge Sarah Howell and Paul Connelly for their assistance with recruitment of the patient sample. We also thank Peter Hackett and Rose Kwa for GCMS and CEDIA toxicology analyses.
Disturbed prepulse inhibition in patients with schizophrenia is consequential to dysfunction of selective attention
Article first published online: 12 OCT 2009
Copyright © 2009 Society for Psychophysiological Research
Volume 47, Issue 2, pages 223–235, March 2010
How to Cite
Scholes, K. E. and Martin-Iverson, M. T. (2010), Disturbed prepulse inhibition in patients with schizophrenia is consequential to dysfunction of selective attention. Psychophysiology, 47: 223–235. doi: 10.1111/j.1469-8986.2009.00927.x
- Issue published online: 8 FEB 2010
- Article first published online: 12 OCT 2009
- (Received January 19, 2008; Accepted April 1, 2009)
- Startle blink
Controversy exists as to the cause of disturbed prepulse inhibition (PPI) in patients with schizophrenia. This study aimed to clarify the nature of PPI in schizophrenia using improved methodology. Startle and PPI were measured in 44 patients with schizophrenia and 32 controls across a range of startling stimulus intensities under two conditions, one while participants were attending to the auditory stimuli (ATTEND condition) and one while participants completed a visual task in order to ensure they were ignoring the auditory stimuli (IGNORE condition). Patients showed reduced PPI of RMAX (reflex capacity) and increased PPI of Hillslope (reflex efficacy) only under the INGORE condition, and failed to show the same pattern of attentional modulation of the reflex parameters as controls. In conclusion, disturbed PPI in schizophrenia appears to result from deficits in selective attention, rather than from preattentive dysfunction.